62890 Current and Emerging Uses of Amniotic Grafts in Skin Regeneration and Wound Healing

The use of dehydrated human amnion/chorion membrane allograft (dHACM) represents a significant advancement in wound care, particularly dermatology. With proven benefits in re-epithelization, dHACM also exhibits anti-inflammatory, anti-scarring, and antimicrobial properties, contributing to faster healing and improved outcomes. A comprehensive search of PubMed, EMBASE, and Ovid MEDLINE databases was conducted using terms such as "placenta,” "amniotic graft wounds,” "placental-derived allografts,” and "dehydrated human amnion/chorion membrane.” The review identifies dHACM as a promising alternative to traditional wound healing methods by secondary intention, with applications in chronic diabetic and non-diabetic ulcers and burn wounds. Additionally, dHACM holds potential in managing chronic and refractory inflammatory skin conditions like psoriasis, eczema, and severe cases such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Although dHACM shows versatility in dermatology with the potential to minimize complications like infection, fibrosis, and scarring, further research is needed to substantiate its emerging applications and solidify its role in advancing wound care and skin regeneration.