A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus

Harvey J. Alter; Judy A. Mikovits; William M. Switzer; Francis W. Ruscetti; Shyh Ching Lo; Nancy Klimas; Anthony L. Komaroff; Jose G. Montoya; Lucinda Bateman; Susan Levine; Daniel Peterson; Bruce Levin; Maureen R. Hanson; Afia Genfi; Meera Bhat; Haoqiang Zheng; Richard Wang; Bingjie Li; Guo Chiuan Hung; Li Ling Lee; Stephen Sameroff; Walid Heneine; John Coffin; Mady Hornig; W. Ian Lipkin

doi:10.1128/mBio.00266-12

A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus

Harvey J. Alter
, Judy A. Mikovits
, William M. Switzer
, Francis W. Ruscetti
, Shyh Ching Lo
, Nancy Klimas
, Anthony L. Komaroff
, Jose G. Montoya
, Lucinda Bateman
, Susan Levine
, Daniel Peterson
, Bruce Levin
, Maureen R. Hanson
, Afia Genfi
, Meera Bhat
, Haoqiang Zheng
, Richard Wang
, Bingjie Li
, Guo Chiuan Hung
, Li Ling Lee

Stephen Sameroff, Walid Heneine, John Coffin, Mady Hornig, W. Ian Lipkin

Research output: Contribution to journal › Article › peer-review

Abstract

The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.

Original language	English
Article number	e00266-12
Journal	mBio
Volume	3
Issue number	5
DOIs	https://doi.org/10.1128/mBio.00266-12
State	Published - 2012

ASJC Scopus Subject Areas

Microbiology
Virology

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Alter, H. J., Mikovits, J. A., Switzer, W. M., Ruscetti, F. W., Lo, S. C., Klimas, N., Komaroff, A. L., Montoya, J. G., Bateman, L., Levine, S., Peterson, D., Levin, B., Hanson, M. R., Genfi, A., Bhat, M., Zheng, H., Wang, R., Li, B., Hung, G. C., ... Lipkin, W. I. (2012). A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus. mBio, 3(5), Article e00266-12. https://doi.org/10.1128/mBio.00266-12

A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus. / Alter, Harvey J.; Mikovits, Judy A.; Switzer, William M. et al.
In: mBio, Vol. 3, No. 5, e00266-12, 2012.

Research output: Contribution to journal › Article › peer-review

Alter, HJ, Mikovits, JA, Switzer, WM, Ruscetti, FW, Lo, SC, Klimas, N, Komaroff, AL, Montoya, JG, Bateman, L, Levine, S, Peterson, D, Levin, B, Hanson, MR, Genfi, A, Bhat, M, Zheng, H, Wang, R, Li, B, Hung, GC, Lee, LL, Sameroff, S, Heneine, W, Coffin, J, Hornig, M & Lipkin, WI 2012, 'A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus', mBio, vol. 3, no. 5, e00266-12. https://doi.org/10.1128/mBio.00266-12

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title = "A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus",

abstract = "The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.",

author = "Alter, \{Harvey J.\} and Mikovits, \{Judy A.\} and Switzer, \{William M.\} and Ruscetti, \{Francis W.\} and Lo, \{Shyh Ching\} and Nancy Klimas and Komaroff, \{Anthony L.\} and Montoya, \{Jose G.\} and Lucinda Bateman and Susan Levine and Daniel Peterson and Bruce Levin and Hanson, \{Maureen R.\} and Afia Genfi and Meera Bhat and Haoqiang Zheng and Richard Wang and Bingjie Li and Hung, \{Guo Chiuan\} and Lee, \{Li Ling\} and Stephen Sameroff and Walid Heneine and John Coffin and Mady Hornig and Lipkin, \{W. Ian\}",

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AU - Alter, Harvey J.

AU - Mikovits, Judy A.

AU - Switzer, William M.

AU - Ruscetti, Francis W.

AU - Lo, Shyh Ching

AU - Klimas, Nancy

AU - Komaroff, Anthony L.

AU - Montoya, Jose G.

AU - Bateman, Lucinda

AU - Levine, Susan

AU - Peterson, Daniel

AU - Levin, Bruce

AU - Hanson, Maureen R.

AU - Genfi, Afia

AU - Bhat, Meera

AU - Zheng, Haoqiang

AU - Wang, Richard

AU - Li, Bingjie

AU - Hung, Guo Chiuan

AU - Lee, Li Ling

AU - Sameroff, Stephen

AU - Heneine, Walid

AU - Coffin, John

AU - Hornig, Mady

AU - Lipkin, W. Ian

PY - 2012

Y1 - 2012

N2 - The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.

AB - The disabling disorder known as chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) has been linked in two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leukemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients continue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.

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A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus

Abstract

ASJC Scopus Subject Areas

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