Accumulation of D-Aspartic Acid with Age in the Human Brain

Eugene H Man; Mark Sandhouse; Jonathan Burg; George H Fisher

Accumulation of D-Aspartic Acid with Age in the Human Brain

Eugene H Man
, Mark Sandhouse
, Jonathan Burg
, George H Fisher

Research output: Contribution to journal › Article › peer-review

Abstract

An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.

Original language	American English
Journal	Science
Volume	220
State	Published - Jun 1 1983

Disciplines

Medical Specialties
Medicine and Health Sciences
Osteopathic Medicine and Osteopathy

Cite this

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title = "Accumulation of D-Aspartic Acid with Age in the Human Brain",

abstract = " An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.",

author = "Man, \{Eugene H\} and Mark Sandhouse and Jonathan Burg and Fisher, \{George H\}",

year = "1983",

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language = "American English",

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journal = "Science",

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T1 - Accumulation of D-Aspartic Acid with Age in the Human Brain

AU - Man, Eugene H

AU - Sandhouse, Mark

AU - Burg, Jonathan

AU - Fisher, George H

PY - 1983/6/1

Y1 - 1983/6/1

N2 - An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.

AB - An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.

UR - https://nsuworks.nova.edu/hpd_com_faculty_articles/560

M3 - Article

SN - 0036-8075

VL - 220

JO - Science

JF - Science

ER -

Accumulation of D-Aspartic Acid with Age in the Human Brain

Abstract

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