Advanced nanoscale delivery systems for mRNA-based vaccines

Maha Mobasher; Rais Ansari; Ana M. Castejon; Jaleh Barar; Yadollah Omidi

doi:10.1016/j.bbagen.2024.130558

Advanced nanoscale delivery systems for mRNA-based vaccines

Research output: Contribution to journal › Review article › peer-review

Abstract

The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of mRNA to target cells. A variety of nanoscale vaccine delivery systems (VDSs) have been explored for this purpose, including lipid nanoparticles (LNPs), liposomes, and polymeric nanoparticles made from biocompatible polymers such as poly(lactic-co-glycolic acid), as well as viral vectors and lipid-polymer hybrid complexes. Among these, LNPs are particularly notable for their efficiency in encapsulating and protecting mRNA. These nanoscale VDSs can be engineered to enhance stability and facilitate uptake by cells. The choice of delivery system depends on factors like the specific mRNA vaccine, target cell types, stability requirements, and desired immune response. In this review, we shed light on recent advances in delivery mechanisms for self-amplifying RNA (saRNA) vaccines, emphasizing groundbreaking studies on nanoscale delivery systems aimed at improving the efficacy and safety of mRNA/saRNA vaccines.

Original language	English
Article number	130558
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1868
Issue number	3
DOIs	https://doi.org/10.1016/j.bbagen.2024.130558
State	Published - Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier B.V.

Funding

The authors would like to express their gratitude for the support received through the HPD Grant (#334643), generously provided by the Barry and Judy Silverman College of Pharmacy at Nova Southeastern University.

Funders	Funder number
Nova Southeastern University	334643

ASJC Scopus Subject Areas

Biophysics
Biochemistry
Molecular Biology

Keywords

mRNA vaccines
Nanoparticles
Self-amplifying RNA (saRNA) vaccines
Vaccine delivery systems
Viral and nonviral vectors

Disciplines

Molecular Biology
Biochemistry, Biophysics, and Structural Biology

Access to Document

10.1016/j.bbagen.2024.130558

Cite this

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title = "Advanced nanoscale delivery systems for mRNA-based vaccines",

abstract = "The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of mRNA to target cells. A variety of nanoscale vaccine delivery systems (VDSs) have been explored for this purpose, including lipid nanoparticles (LNPs), liposomes, and polymeric nanoparticles made from biocompatible polymers such as poly(lactic-co-glycolic acid), as well as viral vectors and lipid-polymer hybrid complexes. Among these, LNPs are particularly notable for their efficiency in encapsulating and protecting mRNA. These nanoscale VDSs can be engineered to enhance stability and facilitate uptake by cells. The choice of delivery system depends on factors like the specific mRNA vaccine, target cell types, stability requirements, and desired immune response. In this review, we shed light on recent advances in delivery mechanisms for self-amplifying RNA (saRNA) vaccines, emphasizing groundbreaking studies on nanoscale delivery systems aimed at improving the efficacy and safety of mRNA/saRNA vaccines.",

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author = "Maha Mobasher and Rais Ansari and Castejon, \{Ana M.\} and Jaleh Barar and Yadollah Omidi",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier B.V.",

year = "2024",

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doi = "10.1016/j.bbagen.2024.130558",

language = "English",

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T1 - Advanced nanoscale delivery systems for mRNA-based vaccines

AU - Mobasher, Maha

AU - Ansari, Rais

AU - Castejon, Ana M.

AU - Barar, Jaleh

AU - Omidi, Yadollah

PY - 2024/3

Y1 - 2024/3

N2 - The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of mRNA to target cells. A variety of nanoscale vaccine delivery systems (VDSs) have been explored for this purpose, including lipid nanoparticles (LNPs), liposomes, and polymeric nanoparticles made from biocompatible polymers such as poly(lactic-co-glycolic acid), as well as viral vectors and lipid-polymer hybrid complexes. Among these, LNPs are particularly notable for their efficiency in encapsulating and protecting mRNA. These nanoscale VDSs can be engineered to enhance stability and facilitate uptake by cells. The choice of delivery system depends on factors like the specific mRNA vaccine, target cell types, stability requirements, and desired immune response. In this review, we shed light on recent advances in delivery mechanisms for self-amplifying RNA (saRNA) vaccines, emphasizing groundbreaking studies on nanoscale delivery systems aimed at improving the efficacy and safety of mRNA/saRNA vaccines.

AB - The effectiveness of messenger RNA (mRNA) vaccines, especially those designed for COVID-19, relies heavily on sophisticated delivery systems that ensure efficient delivery of mRNA to target cells. A variety of nanoscale vaccine delivery systems (VDSs) have been explored for this purpose, including lipid nanoparticles (LNPs), liposomes, and polymeric nanoparticles made from biocompatible polymers such as poly(lactic-co-glycolic acid), as well as viral vectors and lipid-polymer hybrid complexes. Among these, LNPs are particularly notable for their efficiency in encapsulating and protecting mRNA. These nanoscale VDSs can be engineered to enhance stability and facilitate uptake by cells. The choice of delivery system depends on factors like the specific mRNA vaccine, target cell types, stability requirements, and desired immune response. In this review, we shed light on recent advances in delivery mechanisms for self-amplifying RNA (saRNA) vaccines, emphasizing groundbreaking studies on nanoscale delivery systems aimed at improving the efficacy and safety of mRNA/saRNA vaccines.

KW - mRNA vaccines

KW - Nanoparticles

KW - Self-amplifying RNA (saRNA) vaccines

KW - Vaccine delivery systems

KW - Viral and nonviral vectors

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DO - 10.1016/j.bbagen.2024.130558

M3 - Review article

C2 - 38185238

AN - SCOPUS:85182193455

SN - 0304-4165

VL - 1868

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 3

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ER -

Advanced nanoscale delivery systems for mRNA-based vaccines

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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