Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots

Justin B. Domena; Braulio C.L.B. Ferreira; Emel K. Cilingir; Yiqun Zhou; Jiuyan Chen; Qiaxian R. Johnson; Bhanu P.S. Chauhan; M. Bartoli; A. Tagliaferro; Steven Vanni; Regina M. Graham; Roger M. Leblanc

doi:10.1016/j.jcis.2023.07.107

Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots

Justin B. Domena
, Braulio C.L.B. Ferreira
, Emel K. Cilingir
, Yiqun Zhou
, Jiuyan Chen
, Qiaxian R. Johnson
, Bhanu P.S. Chauhan
, M. Bartoli
, A. Tagliaferro
, Steven Vanni
, Regina M. Graham
, Roger M. Leblanc

Research output: Contribution to journal › Article › peer-review

Abstract

Over time, the interest in developing stable photosensitizers (PS) which both absorb and emit light in the red region (650 and 950 nm) has gained noticeable interest. Recently, carbon dots (CDs) have become the material of focus to act as a PS due to their high extinction coefficient, low cytotoxicity, and both high photo and thermal stability. In this work, a Federal and Drug Association (FDA) approved Near Infra-Red (NIR) organic fluorophore used for photo-imaging, indocyanine green (ICG), has been explored as a precursor to develop water-soluble red emissive CDs which possess red emission at 697 nm. Furthermore, our material was found to yield favorable red-imaging capabilities of glioblastoma stem-like cells (GSCs) meanwhile boasting low toxicity. Additionally with post modifications, our CDs have been found to have selectivity towards tumors over healthy tissue as well as crossing the blood-brain barrier (BBB) in zebrafish models.

Original language	English
Pages (from-to)	1619-1637
Number of pages	19
Journal	Journal of Colloid and Interface Science
Volume	650
DOIs	https://doi.org/10.1016/j.jcis.2023.07.107
State	Published - Nov 15 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

Keywords

Blood brain barrier
Carbon dots
Cell imaging
Glioblastoma
Red emission

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10.1016/j.jcis.2023.07.107

Cite this

Domena, J. B., Ferreira, B. C. L. B., Cilingir, E. K., Zhou, Y., Chen, J., Johnson, Q. R., Chauhan, B. P. S., Bartoli, M., Tagliaferro, A., Vanni, S., Graham, R. M., & Leblanc, R. M. (2023). Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots. Journal of Colloid and Interface Science, 650, 1619-1637. https://doi.org/10.1016/j.jcis.2023.07.107

Domena, JB, Ferreira, BCLB, Cilingir, EK, Zhou, Y, Chen, J, Johnson, QR, Chauhan, BPS, Bartoli, M, Tagliaferro, A, Vanni, S, Graham, RM & Leblanc, RM 2023, 'Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots', Journal of Colloid and Interface Science, vol. 650, pp. 1619-1637. https://doi.org/10.1016/j.jcis.2023.07.107

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title = "Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots",

abstract = "Over time, the interest in developing stable photosensitizers (PS) which both absorb and emit light in the red region (650 and 950 nm) has gained noticeable interest. Recently, carbon dots (CDs) have become the material of focus to act as a PS due to their high extinction coefficient, low cytotoxicity, and both high photo and thermal stability. In this work, a Federal and Drug Association (FDA) approved Near Infra-Red (NIR) organic fluorophore used for photo-imaging, indocyanine green (ICG), has been explored as a precursor to develop water-soluble red emissive CDs which possess red emission at 697 nm. Furthermore, our material was found to yield favorable red-imaging capabilities of glioblastoma stem-like cells (GSCs) meanwhile boasting low toxicity. Additionally with post modifications, our CDs have been found to have selectivity towards tumors over healthy tissue as well as crossing the blood-brain barrier (BBB) in zebrafish models.",

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doi = "10.1016/j.jcis.2023.07.107",

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AU - Cilingir, Emel K.

AU - Zhou, Yiqun

AU - Chen, Jiuyan

AU - Johnson, Qiaxian R.

AU - Chauhan, Bhanu P.S.

AU - Bartoli, M.

AU - Tagliaferro, A.

AU - Vanni, Steven

AU - Graham, Regina M.

AU - Leblanc, Roger M.

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AB - Over time, the interest in developing stable photosensitizers (PS) which both absorb and emit light in the red region (650 and 950 nm) has gained noticeable interest. Recently, carbon dots (CDs) have become the material of focus to act as a PS due to their high extinction coefficient, low cytotoxicity, and both high photo and thermal stability. In this work, a Federal and Drug Association (FDA) approved Near Infra-Red (NIR) organic fluorophore used for photo-imaging, indocyanine green (ICG), has been explored as a precursor to develop water-soluble red emissive CDs which possess red emission at 697 nm. Furthermore, our material was found to yield favorable red-imaging capabilities of glioblastoma stem-like cells (GSCs) meanwhile boasting low toxicity. Additionally with post modifications, our CDs have been found to have selectivity towards tumors over healthy tissue as well as crossing the blood-brain barrier (BBB) in zebrafish models.

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Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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