An Assessment of the Antibacterial Efficacy of the GentleWave System in Comparison to Other Endodontic Irrigation Systems: A Systematic Review

Objectives: This systematic review evaluated the antibacterial efficacy of the GentleWave system compared with other endodontic irrigation systems. Materials and Methods: A comprehensive literature search was conducted across multiple databases (PubMed, MEDLINE, Web of Science, Scopus). The eligibility criteria were formulated using the PICOS framework, focusing on the antibacterial efficacy of the GentleWave system compared to other irrigation methods. A total of 2327 articles were screened, with five meeting the selection criteria for inclusion. Four studies were conducted in vitro, one in ex vivo, and various tooth types were tested. A bias assessment was conducted using the QUIN tool. Results: Four studies had a low risk of bias, with one study scoring medium risk. All concluded that the GentleWave system significantly reduced microbial counts. Conclusions: Emerging evidence suggests that GentleWave may provide superior antibacterial efficacy in root canal therapy, making it a compelling option. However, further research is needed to confirm its benefits and promote broader adoption.