Abstract
Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine with several biological functions such as inflammatory effects, proliferation and differentiation of B lymphocytes, T-cell activation, and apoptotic function. Angiotensin (Ang) II induce IL-6 secretion in cultured astrocytes and the effect of Ang III to induce IL-6 production in vascular smooth muscle cells (VSMCs) has not been described yet. In this present study, we investigated in VSMCs of Wistar rats and spontaneously hypertensive rats (SHRs), the effect of Ang III in induction the secretion of IL-6. Interestingly, in Wistar VSMCs, Ang II and III were significantly induced IL-6 secretion in the time dependent manner. However, the IL-6 secretion mediated by Ang II and III was significantly greater in VSMCs of SHRs. In the hypertensive state, they have similar time effect in stimulation of the IL-6 production. Ang III promoted IL-6 secretion via the action on AT1 receptors, as losartan (AT1 receptor antagonist) blocked this effect. AG490 (JAK2) completely diminished IL-6 secretion induced by Ang III, so JAK2 importance could not be overlook in IL-6 secretion. Overall, the findings elucidate the pro-inflammatory effect of Ang III in VSMCs through stimulation of IL-6 secretion and activation of AT1 receptors.
Support or Funding Information
The Saudi Arabian Cultural Mission (SACM)
This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
| Original language | American English |
|---|---|
| Journal | The FASEB Journal |
| Volume | 33 |
| State | Published - Apr 1 2019 |
Keywords
- angiotensin-III
- astrocytes
- inflammation
- vascular smooth muscle cells (VSMCs)
Disciplines
- Medicine and Health Sciences
- Pharmacy and Pharmaceutical Sciences