Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

Theoharis C. Theoharides; Werner Sieghart; Paul Greengard; William W. Douglas

doi:10.1126/science.6153130

Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

Theoharis C. Theoharides
, Werner Sieghart
, Paul Greengard
, William W. Douglas

Research output: Contribution to journal › Article › peer-review

202 Scopus citations

Abstract

Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.

Original language	English
Pages (from-to)	80-82
Number of pages	3
Journal	Science
Volume	207
Issue number	4426
DOIs	https://doi.org/10.1126/science.6153130
State	Published - 1980
Externally published	Yes

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title = "Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein",

abstract = "Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.",

author = "Theoharides, \{Theoharis C.\} and Werner Sieghart and Paul Greengard and Douglas, \{William W.\}",

year = "1980",

doi = "10.1126/science.6153130",

language = "English",

volume = "207",

pages = "80--82",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4426",

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T1 - Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

AU - Theoharides, Theoharis C.

AU - Sieghart, Werner

AU - Greengard, Paul

AU - Douglas, William W.

PY - 1980

Y1 - 1980

N2 - Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.

AB - Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.

UR - https://www.scopus.com/pages/publications/0018899649

UR - https://www.scopus.com/pages/publications/0018899649#tab=citedBy

U2 - 10.1126/science.6153130

DO - 10.1126/science.6153130

M3 - Article

C2 - 6153130

AN - SCOPUS:0018899649

SN - 0036-8075

VL - 207

SP - 80

EP - 82

JO - Science

JF - Science

IS - 4426

ER -

Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

Abstract

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