Abstract
The effects of arylamine spider toxins on synaptic transmission in rat hippocampal slices were investigated. Two different responses were monitored: the AMPA receptor‐mediated population spike recorded in control buffer (selectively antagonized by DNQX) and the NMDA receptor‐mediated EPSP recorded in nominally magnesium‐free buffer containing 20 μM DNQX (selectively antagonized by AP5, AP7, and dizocilpine (MK‐801)). The synthetic arylamine spider toxins JSTX‐3, argiotoxin‐636, and argiotoxin‐659 were 26 to 73 times more potent at antagonizing the NMDA receptor‐mediated EPSP (IC50 values ranging from 12 to 24 μM) than the AMPA receptor‐mediated population spike (IC50 values ranging from 612 to 878 μM). These results indicate that arylamine spider toxins are selective antagonists of NMDA receptors in the mammalian CNS.
| Original language | English |
|---|---|
| Pages (from-to) | 244-250 |
| Number of pages | 7 |
| Journal | Synapse |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1991 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Cellular and Molecular Neuroscience
Keywords
- AMPA
- Argiotoxins
- Glutamate receptors
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