TY - JOUR
T1 - Autism and immunity
T2 - Revisited study
AU - Castellani, Maria Luisa
AU - Conti, C. M.
AU - Kempuraj, D. J.
AU - Salini, V.
AU - Vecchiet, J.
AU - Tetè, S.
AU - Ciampoli, C.
AU - Conti, F.
AU - Cerulli, G.
AU - Caraffa, A.
AU - Antinolfi, P.
AU - Galzio, R.
AU - Shaik, Y.
AU - Theoharides, T. C.
AU - De Amicis, D.
AU - Perrella, A.
AU - Cuccurullo, C.
AU - Boscolo, P.
AU - Felaco, M.
AU - Doyle, R.
AU - Verrocchio, C.
AU - Fulcheri, M.
PY - 2009
Y1 - 2009
N2 - Autism spectrum disorder is of interest neurochemically because it represents a relatively homogeneous disorder with regard to disease development, abnormal cognitive development and intellectual development disturbance. A consistent finding in autistic children is a high number of mast cells and a high level of serotonin which is also found at elevated concentrations in the urine of autistic patients. In addition, a dysfunction of clinical conditions, such as gastrointestinal and immunological symptoms, is frequently noted in autistic children, however, IgE does not appear to be prevalent in these children but probably an increase of cytokines/chemokines produced by mast cells at an early age may play an important role. Therefore an immune hypothesis, involving also autoimmunity, is one possible pathogenetic mechanism in autism. In conclusion, mast cell activation could contribute to immune and neuroinflammatory abnormalities that are evident in patients with autism spectrum disorders.
AB - Autism spectrum disorder is of interest neurochemically because it represents a relatively homogeneous disorder with regard to disease development, abnormal cognitive development and intellectual development disturbance. A consistent finding in autistic children is a high number of mast cells and a high level of serotonin which is also found at elevated concentrations in the urine of autistic patients. In addition, a dysfunction of clinical conditions, such as gastrointestinal and immunological symptoms, is frequently noted in autistic children, however, IgE does not appear to be prevalent in these children but probably an increase of cytokines/chemokines produced by mast cells at an early age may play an important role. Therefore an immune hypothesis, involving also autoimmunity, is one possible pathogenetic mechanism in autism. In conclusion, mast cell activation could contribute to immune and neuroinflammatory abnormalities that are evident in patients with autism spectrum disorders.
UR - https://www.scopus.com/pages/publications/62649087603
UR - https://www.scopus.com/pages/publications/62649087603#tab=citedBy
U2 - 10.1177/039463200902200103
DO - 10.1177/039463200902200103
M3 - Editorial
C2 - 19309548
AN - SCOPUS:62649087603
SN - 0394-6320
VL - 22
SP - 15
EP - 19
JO - International Journal of Immunopathology and Pharmacology
JF - International Journal of Immunopathology and Pharmacology
IS - 1
ER -