Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli

James T. McKenna; Stephen Thankachan; David S. Uygun; Charu Shukla; James M. McNally; Felipe L. Schiffino; Joshua Cordeira; Fumi Katsuki; Janneke C. Zant; Mackenzie C. Gamble; Karl Deisseroth; Robert W. McCarley; Ritchie E. Brown; Robert E. Strecker; Radhika Basheer

doi:10.1016/j.cub.2020.04.029

Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli

James T. McKenna
, Stephen Thankachan
, David S. Uygun
, Charu Shukla
, James M. McNally
, Felipe L. Schiffino
, Joshua Cordeira
, Fumi Katsuki
, Janneke C. Zant
, Mackenzie C. Gamble
, Karl Deisseroth
, Robert W. McCarley
, Ritchie E. Brown
, Robert E. Strecker
, Radhika Basheer

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Brief arousals from sleep in sleep apnea and other disorders hinder the restorative effects of sleep. Using optogenetic techniques in mice, McKenna et al. identify basal forebrain parvalbumin neurons as an important contributor to brief arousals from sleep elicited by increased carbon dioxide levels or acoustic stimuli.

Original language	English
Pages (from-to)	2379-2385.e4
Journal	Current Biology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1016/j.cub.2020.04.029
State	Published - Jun 22 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

Keywords

ArchT
GABAergic
ascending reticular activating system
basal forebrain
channelrhodopsin2
cortical arousal
hypercarbia
parvalbumin
sleep apnea
sleep-wake

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10.1016/j.cub.2020.04.029

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McKenna, J. T., Thankachan, S., Uygun, D. S., Shukla, C., McNally, J. M., Schiffino, F. L., Cordeira, J., Katsuki, F., Zant, J. C., Gamble, M. C., Deisseroth, K., McCarley, R. W., Brown, R. E., Strecker, R. E., & Basheer, R. (2020). Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli. Current Biology, 30(12), 2379-2385.e4. https://doi.org/10.1016/j.cub.2020.04.029

McKenna, JT, Thankachan, S, Uygun, DS, Shukla, C, McNally, JM, Schiffino, FL, Cordeira, J, Katsuki, F, Zant, JC, Gamble, MC, Deisseroth, K, McCarley, RW, Brown, RE, Strecker, RE & Basheer, R 2020, 'Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli', Current Biology, vol. 30, no. 12, pp. 2379-2385.e4. https://doi.org/10.1016/j.cub.2020.04.029

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Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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