TY - JOUR
T1 - Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts
AU - Hosokawa, Yoshitaka
AU - Hosokawa, Ikuko
AU - Shindo, Satoru
AU - Ozaki, Kazumi
AU - Nakanishi, Tadashi
AU - Nakae, Hideaki
AU - Matsuo, Takashi
PY - 2011/6
Y1 - 2011/6
N2 - CXC chemokine ligand 10 (CXCL10) plays an important role in the infiltration of Th1 cells and thus in the exacerbation of periodontal disease. Theaflavin-3,3′-digallate (TFDG), polyphenol in black tea, has some beneficial effects but the effect of TFDG on CXCL10 production from human gingival fibroblasts (HGFs) is uncertain. In this study, we investigated the mechanisms by which TFDG may inhibit oncostatin M (OSM)-induced CXCL10 production in human gingival fibroblasts. TFDG prevented OSM-mediated CXCL10 production by HGFs in a dose dependent manner. TFDG significantly inhibited OSM-induced phosphorylation of c-Jun N terminal kinase (JNK), protein kinase B (Akt) (Ser473) that are related to CXCL10 production from OSM-stimulated HGFs. In addition, TFDG suppressed OSM receptor (OSMR) β expression on HGFs. These data provide a novel mechanism where the black tea flavonoid, theaflavin, could provide direct benefits in periodontal disease.
AB - CXC chemokine ligand 10 (CXCL10) plays an important role in the infiltration of Th1 cells and thus in the exacerbation of periodontal disease. Theaflavin-3,3′-digallate (TFDG), polyphenol in black tea, has some beneficial effects but the effect of TFDG on CXCL10 production from human gingival fibroblasts (HGFs) is uncertain. In this study, we investigated the mechanisms by which TFDG may inhibit oncostatin M (OSM)-induced CXCL10 production in human gingival fibroblasts. TFDG prevented OSM-mediated CXCL10 production by HGFs in a dose dependent manner. TFDG significantly inhibited OSM-induced phosphorylation of c-Jun N terminal kinase (JNK), protein kinase B (Akt) (Ser473) that are related to CXCL10 production from OSM-stimulated HGFs. In addition, TFDG suppressed OSM receptor (OSMR) β expression on HGFs. These data provide a novel mechanism where the black tea flavonoid, theaflavin, could provide direct benefits in periodontal disease.
KW - CXCL10
KW - Fibroblasts
KW - Oncostatin M
KW - Theaflavin
UR - https://www.scopus.com/pages/publications/79955824810
UR - https://www.scopus.com/pages/publications/79955824810#tab=citedBy
U2 - 10.1016/j.intimp.2011.01.009
DO - 10.1016/j.intimp.2011.01.009
M3 - Article
C2 - 21255696
AN - SCOPUS:79955824810
SN - 1567-5769
VL - 11
SP - 670
EP - 674
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 6
ER -