Abstract
Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B–Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.
| Original language | American English |
|---|---|
| Pages (from-to) | 2198-2209 |
| Number of pages | 12 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 16 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jan 1 2018 |
Bibliographical note
Publisher Copyright:© 2018 The Royal Society of Chemistry.
Funding
This work was supported by the grant for joint funding, Ratchadaphiseksomphot endowment fund, and the NSF Grants EPS-0554328, EPS-1003907, and DGE-1144676.
| Funders | Funder number |
|---|---|
| National Science Foundation | DGE-1144676, EPS-0554328, EPS-1003907 |
| Norsk Sykepleierforbund |
ASJC Scopus Subject Areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Disciplines
- Medicine and Health Sciences
- Pharmacy and Pharmaceutical Sciences
- Biochemistry
- Physical Chemistry
- Organic Chemistry
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