Cell mediated immunity in brain tumour patients - An in vitro analysis using a leucocyte migration inhibition test

Cell mediated immunity in brain tumour patients before and after treatment, and with reference to histological type of the tumour and site of lesion, was assessed by an in vitro leucocyte migration inhibition (LMI) test. The LMI index increased in both benign and malignant tumour patients before and after treatment as compared with control subjects. However, there was no significant change after treatment as compared to the pre-treatment level nor any significant alteration in the index with reference to either the type of tumour or site of lesion. The observed change may be due to an altered helper/suppressor cell ratio.