@article{7d178203230443ddb94585bb322ceb3f,
title = "Characterization of MYC-Induced Tumorigenesis by in Situ Lipid Profiling",
abstract = "We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and off has led to the discovery of highly specific lipid molecules associated with MYC-induced tumor onset. We are able to distinguish normal from MYC-induced malignant cells. Our approach provides a strategy to define a precise molecular picture at a resolution of about 200 μm that may be useful in identifying lipid molecules that define how the MYC oncogene initiates and maintains tumorigenesis. {\textcopyright} 2013 American Chemical Society.",
keywords = "Animals, Spectrometry, Mass, Electrospray Ionization, Carcinoma, Hepatocellular/genetics, Mice, Transgenic, Proto-Oncogene Proteins c-myc/genetics, Lipid Metabolism/genetics, Mice, Lipids/genetics, Liver Neoplasms/genetics, Carcinogenesis/genetics, Disease Models, Animal",
author = "Perry, \{Richard H.\} and Bellovin, \{David I.\} and Shroff, \{Emelyn H.\} and Ismail, \{Ali I.\} and Tahera Zubuawala and Felsher, \{Dean W.\} and Zare, \{Richard N.\}",
year = "2013",
month = may,
day = "7",
doi = "10.1021/ac400479j",
language = "American English",
volume = "85",
pages = "4259--4262",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "9",
}