Circadian variations in radioligand binding to muscarine receptors in rat brain dependent upon endogenous agonist occupation

Deborah C. Mash; Donna D. Flynn; Lynn Kalinoski; Lincoln T. Potter

doi:10.1016/0006-8993(85)90712-7

Circadian variations in radioligand binding to muscarine receptors in rat brain dependent upon endogenous agonist occupation

Deborah C. Mash
, Donna D. Flynn
, Lynn Kalinoski
, Lincoln T. Potter

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Although total levels of muscarine receptors in the rat forebrain and brainstem are constant at different times of day, there are large circadian changes in the numbers and carbachol-affinities of unoccupied receptors, which appear to reflect varying levels of endogenous acetylcholine-receptor complexes and the activity of cholinergic synapses.

Original language	English
Pages (from-to)	35-38
Number of pages	4
Journal	Brain Research
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)90712-7
State	Published - Apr 1 1985
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

acetylcholine
circadian rhythm
muscarine receptors

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10.1016/0006-8993(85)90712-7

Cite this

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title = "Circadian variations in radioligand binding to muscarine receptors in rat brain dependent upon endogenous agonist occupation",

abstract = "Although total levels of muscarine receptors in the rat forebrain and brainstem are constant at different times of day, there are large circadian changes in the numbers and carbachol-affinities of unoccupied receptors, which appear to reflect varying levels of endogenous acetylcholine-receptor complexes and the activity of cholinergic synapses.",

keywords = "acetylcholine, circadian rhythm, muscarine receptors",

author = "Mash, \{Deborah C.\} and Flynn, \{Donna D.\} and Lynn Kalinoski and Potter, \{Lincoln T.\}",

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AU - Mash, Deborah C.

AU - Flynn, Donna D.

AU - Kalinoski, Lynn

AU - Potter, Lincoln T.

PY - 1985/4/1

Y1 - 1985/4/1

N2 - Although total levels of muscarine receptors in the rat forebrain and brainstem are constant at different times of day, there are large circadian changes in the numbers and carbachol-affinities of unoccupied receptors, which appear to reflect varying levels of endogenous acetylcholine-receptor complexes and the activity of cholinergic synapses.

AB - Although total levels of muscarine receptors in the rat forebrain and brainstem are constant at different times of day, there are large circadian changes in the numbers and carbachol-affinities of unoccupied receptors, which appear to reflect varying levels of endogenous acetylcholine-receptor complexes and the activity of cholinergic synapses.

KW - acetylcholine

KW - circadian rhythm

KW - muscarine receptors

UR - https://www.scopus.com/pages/publications/0021911960

UR - https://www.scopus.com/pages/publications/0021911960#tab=citedBy

U2 - 10.1016/0006-8993(85)90712-7

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AN - SCOPUS:0021911960

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JO - Brain Research

JF - Brain Research

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ER -

Circadian variations in radioligand binding to muscarine receptors in rat brain dependent upon endogenous agonist occupation

Abstract

ASJC Scopus Subject Areas

Keywords

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