Clinical implications of vitamin B12 as redox-active cofactor

Annette K. Offringa; Arno R. Bourgonje; Matthew S. Schrier; Richard C. Deth; Harry van Goor

doi:10.1016/j.molmed.2021.07.002

Clinical implications of vitamin B₁₂ as redox-active cofactor

Annette K. Offringa
, Arno R. Bourgonje
, Matthew S. Schrier
, Richard C. Deth
, Harry van Goor

Research output: Contribution to journal › Short survey › peer-review

Abstract

Vitamin B12 is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B12 may be clinically used to reduce oxidative stress and preserve cofactor functions.

Original language	English
Pages (from-to)	931-934
Number of pages	4
Journal	Trends in Molecular Medicine
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/j.molmed.2021.07.002
State	Published - Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

ASJC Scopus Subject Areas

Molecular Medicine
Molecular Biology

Keywords

homocysteine
methionine
oxidative stress
redox
vitamin B12

Disciplines

Medical Molecular Biology

Access to Document

10.1016/j.molmed.2021.07.002

Cite this

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abstract = "Vitamin B12 is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B12 may be clinically used to reduce oxidative stress and preserve cofactor functions. ",

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author = "Offringa, \{Annette K.\} and Bourgonje, \{Arno R.\} and Schrier, \{Matthew S.\} and Deth, \{Richard C.\} and \{van Goor\}, Harry",

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AU - Bourgonje, Arno R.

AU - Schrier, Matthew S.

AU - Deth, Richard C.

AU - van Goor, Harry

PY - 2021/10

Y1 - 2021/10

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AB - Vitamin B12 is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B12 may be clinically used to reduce oxidative stress and preserve cofactor functions.

KW - homocysteine

KW - methionine

KW - oxidative stress

KW - redox

KW - vitamin B12

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