Abstract
The review article “Transcription regulation by long non-coding RNAs: mechanisms and disease relevance” by Jorge Ferrer and Nadya Dimitrova, published in Nature Reviews Molecular Cell Biology, explores the complex roles of long non-coding RNAs (lncRNAs) in gene transcription regulation. The authors discuss various mechanisms by which lncRNAs influence transcription, including their functions as cis-regulatory elements, transcription stabilizers, and scaffolds for regulatory complexes. The review also highlights the potential of lncRNAs in disease contexts and their therapeutic applications. However, it is essential to consider the potential limitations in current lncRNA research.
| Original language | English |
|---|---|
| Pages (from-to) | 281-284 |
| Number of pages | 4 |
| Journal | Journal of Translational Genetics and Genomics |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 30 2024 |
Bibliographical note
Publisher Copyright:© The Author(s) 2024.
Funding
This work was supported in part by the funding from the American Heart Association Grant #940594/Narasimman Gurusamy/2022.
ASJC Scopus Subject Areas
- Genetics
- Genetics(clinical)
Keywords
- cis regulation
- disease
- lncRNA
- trans regulation
- transcription regulation
Disciplines
- Genetics
- Medical Genetics
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