Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?

  • Jose Antonio
  • , Darren G. Candow
  • , Scott C. Forbes
  • , Bruno Gualano
  • , Andrew R. Jagim
  • , Richard B. Kreider
  • , Eric S. Rawson
  • , Abbie E. Smith-Ryan
  • , Trisha A. VanDusseldorp
  • , Darryn S. Willoughby
  • , Tim N. Ziegenfuss

Research output: Contribution to journalReview articlepeer-review

Abstract

Supplementing with creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery. Accumulating evidence also suggests that creatine supplementation produces a variety of beneficial effects in older and patient populations. Furthermore, evidence-based research shows that creatine supplementation is relatively well tolerated, especially at recommended dosages (i.e. 3-5 g/day or 0.1 g/kg of body mass/day). Although there are over 500 peer-refereed publications involving creatine supplementation, it is somewhat surprising that questions regarding the efficacy and safety of creatine still remain. These include, but are not limited to: 1. Does creatine lead to water retention? 2. Is creatine an anabolic steroid? 3. Does creatine cause kidney damage/renal dysfunction? 4. Does creatine cause hair loss / baldness? 5. Does creatine lead to dehydration and muscle cramping? 6. Is creatine harmful for children and adolescents? 7. Does creatine increase fat mass? 8. Is a creatine ‘loading-phase’ required? 9. Is creatine beneficial for older adults? 10. Is creatine only useful for resistance / power type activities? 11. Is creatine only effective for males? 12. Are other forms of creatine similar or superior to monohydrate and is creatine stable in solutions/beverages? To answer these questions, an internationally renowned team of research experts was formed to perform an evidence-based scientific evaluation of the literature regarding creatine supplementation.

Original languageEnglish
Article number13
JournalJournal of the International Society of Sports Nutrition
Volume18
Issue number1
DOIs
StatePublished - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

Funding

Not applicable.

ASJC Scopus Subject Areas

  • Food Science
  • Nutrition and Dietetics

Keywords

  • Adverse Effects
  • Anecdotal
  • Research
  • Safety
  • Social Media

Disciplines

  • Food Science
  • Dietetics and Clinical Nutrition

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