Comparative assessment of growth supporting potential of different alginic acid salts

Umadevi Kandalam; Hamid Omidian; Mudasar Mirza

doi:10.1080/00914037.2015.1055630

Comparative assessment of growth supporting potential of different alginic acid salts

Umadevi Kandalam
, Hamid Omidian
, Mudasar Mirza

Research output: Contribution to journal › Article › peer-review

Abstract

This study compares the cell survival of HeLa, osteoblasts (MG 63), and human umbilical cord stem cells (hUMSCs) in three different salts of alginic acid including sodium, potassium, and triethanolamine. While the treatment of the cells with wide range of concentrations of potassium and triethanolamine alginate did not adversely affect the cell growth, higher concentrations of sodium alginate inhibited cell growth on all the cell types tested. Furthermore, the cells encapsulated in potassium alginate beads showed enhanced cell survival compared to the growth in other salts. Our results indicated that potassium alginate can be used with wide varieties of cell types.

Original language	American English
Pages (from-to)	47-53
Number of pages	7
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	65
Issue number	1
DOIs	https://doi.org/10.1080/00914037.2015.1055630
State	Published - Oct 10 2015

Keywords

alginates
cell proliferation
encapsulation
Alginates
cellproliferation

Disciplines

Medicine and Health Sciences
Pharmacy and Pharmaceutical Sciences

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10.1080/00914037.2015.1055630License: Unspecified

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abstract = " This study compares the cell survival of HeLa, osteoblasts (MG 63), and human umbilical cord stem cells (hUMSCs) in three different salts of alginic acid including sodium, potassium, and triethanolamine. While the treatment of the cells with wide range of concentrations of potassium and triethanolamine alginate did not adversely affect the cell growth, higher concentrations of sodium alginate inhibited cell growth on all the cell types tested. Furthermore, the cells encapsulated in potassium alginate beads showed enhanced cell survival compared to the growth in other salts. Our results indicated that potassium alginate can be used with wide varieties of cell types.",

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AU - Mirza, Mudasar

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N2 - This study compares the cell survival of HeLa, osteoblasts (MG 63), and human umbilical cord stem cells (hUMSCs) in three different salts of alginic acid including sodium, potassium, and triethanolamine. While the treatment of the cells with wide range of concentrations of potassium and triethanolamine alginate did not adversely affect the cell growth, higher concentrations of sodium alginate inhibited cell growth on all the cell types tested. Furthermore, the cells encapsulated in potassium alginate beads showed enhanced cell survival compared to the growth in other salts. Our results indicated that potassium alginate can be used with wide varieties of cell types.

AB - This study compares the cell survival of HeLa, osteoblasts (MG 63), and human umbilical cord stem cells (hUMSCs) in three different salts of alginic acid including sodium, potassium, and triethanolamine. While the treatment of the cells with wide range of concentrations of potassium and triethanolamine alginate did not adversely affect the cell growth, higher concentrations of sodium alginate inhibited cell growth on all the cell types tested. Furthermore, the cells encapsulated in potassium alginate beads showed enhanced cell survival compared to the growth in other salts. Our results indicated that potassium alginate can be used with wide varieties of cell types.

KW - alginates

KW - cell proliferation

KW - encapsulation

KW - Alginates

KW - cellproliferation

UR - https://nsuworks.nova.edu/hpd_corx_facarticles/248

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DO - 10.1080/00914037.2015.1055630

M3 - Article

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JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

IS - 1

ER -

Comparative assessment of growth supporting potential of different alginic acid salts

Abstract

Keywords

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