TY - JOUR
T1 - Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data.
AU - Hsiao, F Y
AU - Mullins, C D
AU - Onukwugha, E
AU - Pandya, Naushira
AU - Hanna, N
PY - 2011/8/10
Y1 - 2011/8/10
N2 - OBJECTIVES: To compare the effectiveness and utilization trends of irinotecan (IRI)-based and oxaliplatin (OX)-based regimens with those of 5-fluorouracil and leucovorin (5FU/LV) alone in people aged 66 and older with Stage III colon cancer. DESIGN: Retrospective cohort study. SETTING: Data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare data. PARTICIPANTS: People with Stage III surgically resected colon cancer who received adjuvant chemotherapy were categorized into 5FU/LV-alone (n=3,581), OX-based regimen (n=814), and IRI-based regimen (n=219) subgroups. MEASUREMENTS: Multivariable Cox proportional hazards models examined the effect of chemotherapies on overall survival, colon cancer-specific survival, and noncolon cancer-specific survival. RESULTS: Use of the OX-based regimen increased, and use of the 5FU/LV-alone and IRI-based regimens decreased over time. OX was statistically significantly associated with longer overall survival (hazard ratio (HR) =0.73, 95% confidence interval (CI)=0.62-0.86, P
AB - OBJECTIVES: To compare the effectiveness and utilization trends of irinotecan (IRI)-based and oxaliplatin (OX)-based regimens with those of 5-fluorouracil and leucovorin (5FU/LV) alone in people aged 66 and older with Stage III colon cancer. DESIGN: Retrospective cohort study. SETTING: Data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare data. PARTICIPANTS: People with Stage III surgically resected colon cancer who received adjuvant chemotherapy were categorized into 5FU/LV-alone (n=3,581), OX-based regimen (n=814), and IRI-based regimen (n=219) subgroups. MEASUREMENTS: Multivariable Cox proportional hazards models examined the effect of chemotherapies on overall survival, colon cancer-specific survival, and noncolon cancer-specific survival. RESULTS: Use of the OX-based regimen increased, and use of the 5FU/LV-alone and IRI-based regimens decreased over time. OX was statistically significantly associated with longer overall survival (hazard ratio (HR) =0.73, 95% confidence interval (CI)=0.62-0.86, P
UR - https://nsuworks.nova.edu/hpd_com_faculty_articles/719
U2 - 10.1111/j.1532-5415.2011.03501.x
DO - 10.1111/j.1532-5415.2011.03501.x
M3 - Article
SN - 0002-8614
VL - 59
SP - 1717
EP - 1723
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 9
ER -