Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data.

F Y Hsiao; C D Mullins; E Onukwugha; Naushira Pandya; N Hanna

doi:10.1111/j.1532-5415.2011.03501.x

Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data.

F Y Hsiao
, C D Mullins
, E Onukwugha
, Naushira Pandya
, N Hanna

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

OBJECTIVES: To compare the effectiveness and utilization trends of irinotecan (IRI)-based and oxaliplatin (OX)-based regimens with those of 5-fluorouracil and leucovorin (5FU/LV) alone in people aged 66 and older with Stage III colon cancer. DESIGN: Retrospective cohort study. SETTING: Data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare data. PARTICIPANTS: People with Stage III surgically resected colon cancer who received adjuvant chemotherapy were categorized into 5FU/LV-alone (n=3,581), OX-based regimen (n=814), and IRI-based regimen (n=219) subgroups. MEASUREMENTS: Multivariable Cox proportional hazards models examined the effect of chemotherapies on overall survival, colon cancer-specific survival, and noncolon cancer-specific survival. RESULTS: Use of the OX-based regimen increased, and use of the 5FU/LV-alone and IRI-based regimens decreased over time. OX was statistically significantly associated with longer overall survival (hazard ratio (HR) =0.73, 95% confidence interval (CI)=0.62-0.86, P

Original language	American English
Pages (from-to)	1717-1723
Number of pages	7
Journal	Journal of the American Geriatrics Society
Volume	59
Issue number	9
DOIs	https://doi.org/10.1111/j.1532-5415.2011.03501.x
State	Published - Aug 10 2011

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Medicine and Health Sciences
Osteopathic Medicine and Osteopathy

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Hsiao, F. Y., Mullins, C. D., Onukwugha, E., Pandya, N., & Hanna, N. (2011). Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data. Journal of the American Geriatrics Society, 59(9), 1717-1723. https://doi.org/10.1111/j.1532-5415.2011.03501.x

Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data. / Hsiao, F Y; Mullins, C D; Onukwugha, E et al.
In: Journal of the American Geriatrics Society, Vol. 59, No. 9, 10.08.2011, p. 1717-1723.

Research output: Contribution to journal › Article › peer-review

Hsiao, FY, Mullins, CD, Onukwugha, E, Pandya, N & Hanna, N 2011, 'Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data.', Journal of the American Geriatrics Society, vol. 59, no. 9, pp. 1717-1723. https://doi.org/10.1111/j.1532-5415.2011.03501.x

Hsiao FY, Mullins CD, Onukwugha E, Pandya N, Hanna N. Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data. Journal of the American Geriatrics Society. 2011 Aug 10;59(9):1717-1723. doi: 10.1111/j.1532-5415.2011.03501.x

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abstract = "OBJECTIVES: To compare the effectiveness and utilization trends of irinotecan (IRI)-based and oxaliplatin (OX)-based regimens with those of 5-fluorouracil and leucovorin (5FU/LV) alone in people aged 66 and older with Stage III colon cancer. DESIGN: Retrospective cohort study. SETTING: Data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare data. PARTICIPANTS: People with Stage III surgically resected colon cancer who received adjuvant chemotherapy were categorized into 5FU/LV-alone (n=3,581), OX-based regimen (n=814), and IRI-based regimen (n=219) subgroups. MEASUREMENTS: Multivariable Cox proportional hazards models examined the effect of chemotherapies on overall survival, colon cancer-specific survival, and noncolon cancer-specific survival. RESULTS: Use of the OX-based regimen increased, and use of the 5FU/LV-alone and IRI-based regimens decreased over time. OX was statistically significantly associated with longer overall survival (hazard ratio (HR) =0.73, 95\% confidence interval (CI)=0.62-0.86, P",

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AU - Hsiao, F Y

AU - Mullins, C D

AU - Onukwugha, E

AU - Pandya, Naushira

AU - Hanna, N

PY - 2011/8/10

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N2 - OBJECTIVES: To compare the effectiveness and utilization trends of irinotecan (IRI)-based and oxaliplatin (OX)-based regimens with those of 5-fluorouracil and leucovorin (5FU/LV) alone in people aged 66 and older with Stage III colon cancer. DESIGN: Retrospective cohort study. SETTING: Data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare data. PARTICIPANTS: People with Stage III surgically resected colon cancer who received adjuvant chemotherapy were categorized into 5FU/LV-alone (n=3,581), OX-based regimen (n=814), and IRI-based regimen (n=219) subgroups. MEASUREMENTS: Multivariable Cox proportional hazards models examined the effect of chemotherapies on overall survival, colon cancer-specific survival, and noncolon cancer-specific survival. RESULTS: Use of the OX-based regimen increased, and use of the 5FU/LV-alone and IRI-based regimens decreased over time. OX was statistically significantly associated with longer overall survival (hazard ratio (HR) =0.73, 95% confidence interval (CI)=0.62-0.86, P

AB - OBJECTIVES: To compare the effectiveness and utilization trends of irinotecan (IRI)-based and oxaliplatin (OX)-based regimens with those of 5-fluorouracil and leucovorin (5FU/LV) alone in people aged 66 and older with Stage III colon cancer. DESIGN: Retrospective cohort study. SETTING: Data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare data. PARTICIPANTS: People with Stage III surgically resected colon cancer who received adjuvant chemotherapy were categorized into 5FU/LV-alone (n=3,581), OX-based regimen (n=814), and IRI-based regimen (n=219) subgroups. MEASUREMENTS: Multivariable Cox proportional hazards models examined the effect of chemotherapies on overall survival, colon cancer-specific survival, and noncolon cancer-specific survival. RESULTS: Use of the OX-based regimen increased, and use of the 5FU/LV-alone and IRI-based regimens decreased over time. OX was statistically significantly associated with longer overall survival (hazard ratio (HR) =0.73, 95% confidence interval (CI)=0.62-0.86, P

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Comparative effectiveness of different chemotherapeutic regimens on survival of people aged 66 and older with stage III colon cancer: a "real world" analysis using Surveillance, Epidemiology, and End Results-Medicare data.

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