Complete Protection and Glycosylation of 5-Hydroxy-DL-Lysine

Lindsey Nowland; Beatrix Aukszi

Complete Protection and Glycosylation of 5-Hydroxy-DL-Lysine

Lindsey Nowland
, Beatrix Aukszi

Research output: Contribution to conference › Poster

Abstract

Adiponectin, a protein hormone, has been shown to play a role in preventing the development of atherosclerosis, a common cardiovascular disease. Altering some of the amino acids in adiponectin can provide beneficial effects towards that goal. One such amino acid, Hydroxylysine, can often undergo posttranslational modifications, such as glycosylation. Research done herein focused on carrying out differential protection on three functional groups of hydroxylysine, making it suitable for peptide synthesis and galactosylation of the free hydroxyl group.[p]

Original language	American English
State	Published - Mar 26 2012
Event	Spring Meeting of the American Chemical Society (ACS): Chemistry of Life - San Diego, United States Duration: Mar 25 2012 → Mar 29 2012

Conference

Conference	Spring Meeting of the American Chemical Society (ACS)
Country/Territory	United States
City	San Diego
Period	3/25/12 → 3/29/12

Disciplines

Chemistry

Cite this

@conference{92a73b7955044eba85a26a5c2d9997ac,

title = "Complete Protection and Glycosylation of 5-Hydroxy-DL-Lysine",

abstract = " Adiponectin, a protein hormone, has been shown to play a role in preventing the development of atherosclerosis, a common cardiovascular disease. Altering some of the amino acids in adiponectin can provide beneficial effects towards that goal. One such amino acid, Hydroxylysine, can often undergo posttranslational modifications, such as glycosylation. Research done herein focused on carrying out differential protection on three functional groups of hydroxylysine, making it suitable for peptide synthesis and galactosylation of the free hydroxyl group.[p]",

author = "Lindsey Nowland and Beatrix Aukszi",

year = "2012",

month = mar,

day = "26",

language = "American English",

note = "Spring Meeting of the American Chemical Society (ACS) : Chemistry of Life ; Conference date: 25-03-2012 Through 29-03-2012",

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TY - CONF

T1 - Complete Protection and Glycosylation of 5-Hydroxy-DL-Lysine

AU - Nowland, Lindsey

AU - Aukszi, Beatrix

PY - 2012/3/26

Y1 - 2012/3/26

N2 - Adiponectin, a protein hormone, has been shown to play a role in preventing the development of atherosclerosis, a common cardiovascular disease. Altering some of the amino acids in adiponectin can provide beneficial effects towards that goal. One such amino acid, Hydroxylysine, can often undergo posttranslational modifications, such as glycosylation. Research done herein focused on carrying out differential protection on three functional groups of hydroxylysine, making it suitable for peptide synthesis and galactosylation of the free hydroxyl group.[p]

AB - Adiponectin, a protein hormone, has been shown to play a role in preventing the development of atherosclerosis, a common cardiovascular disease. Altering some of the amino acids in adiponectin can provide beneficial effects towards that goal. One such amino acid, Hydroxylysine, can often undergo posttranslational modifications, such as glycosylation. Research done herein focused on carrying out differential protection on three functional groups of hydroxylysine, making it suitable for peptide synthesis and galactosylation of the free hydroxyl group.[p]

UR - https://nsuworks.nova.edu/cnso_chemphys_facpres/101

M3 - Poster

T2 - Spring Meeting of the American Chemical Society (ACS)

Y2 - 25 March 2012 through 29 March 2012

ER -

Complete Protection and Glycosylation of 5-Hydroxy-DL-Lysine

Abstract

Conference

Disciplines

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