COPS5 (Jab1) Protein increases β Site processing of amyloid precursor protein and amyloid βpeptide generation by stabilizing ranbp9 protein levels

Hongjie Wang; Debleena Dey; Ivan Carrera; Dmitriy Minond; Elisabetta Bianchi; Shaohua Xu; Madepalli K. Lakshmana

doi:10.1074/jbc.M113.476689

COPS5 (Jab1) Protein increases β Site processing of amyloid precursor protein and amyloid βpeptide generation by stabilizing ranbp9 protein levels

Hongjie Wang
, Debleena Dey
, Ivan Carrera
, Dmitriy Minond
, Elisabetta Bianchi
, Shaohua Xu
, Madepalli K. Lakshmana

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background: Increased generation of toxic amyloidβpeptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Results: COPS5 (Jab1) is a novel RanBP9-interacting protein that robustly increases Aβgeneration Conclusion: COPS5 increases Aβgeneration by stabilizing RanBP9 protein levels. Significance: Lowering COPS5 levels may be an effective therapeutic approach for AD.

Original language	English
Pages (from-to)	26668-26677
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M113.476689
State	Published - Sep 13 2013
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.476689

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title = "COPS5 (Jab1) Protein increases β Site processing of amyloid precursor protein and amyloid βpeptide generation by stabilizing ranbp9 protein levels",

abstract = "Background: Increased generation of toxic amyloidβpeptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Results: COPS5 (Jab1) is a novel RanBP9-interacting protein that robustly increases Aβgeneration Conclusion: COPS5 increases Aβgeneration by stabilizing RanBP9 protein levels. Significance: Lowering COPS5 levels may be an effective therapeutic approach for AD. ",

author = "Hongjie Wang and Debleena Dey and Ivan Carrera and Dmitriy Minond and Elisabetta Bianchi and Shaohua Xu and Lakshmana, \{Madepalli K.\}",

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T1 - COPS5 (Jab1) Protein increases β Site processing of amyloid precursor protein and amyloid βpeptide generation by stabilizing ranbp9 protein levels

AU - Wang, Hongjie

AU - Dey, Debleena

AU - Carrera, Ivan

AU - Minond, Dmitriy

AU - Bianchi, Elisabetta

AU - Xu, Shaohua

AU - Lakshmana, Madepalli K.

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: Increased generation of toxic amyloidβpeptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Results: COPS5 (Jab1) is a novel RanBP9-interacting protein that robustly increases Aβgeneration Conclusion: COPS5 increases Aβgeneration by stabilizing RanBP9 protein levels. Significance: Lowering COPS5 levels may be an effective therapeutic approach for AD.

AB - Background: Increased generation of toxic amyloidβpeptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Results: COPS5 (Jab1) is a novel RanBP9-interacting protein that robustly increases Aβgeneration Conclusion: COPS5 increases Aβgeneration by stabilizing RanBP9 protein levels. Significance: Lowering COPS5 levels may be an effective therapeutic approach for AD.

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U2 - 10.1074/jbc.M113.476689

DO - 10.1074/jbc.M113.476689

M3 - Article

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JF - Journal of Biological Chemistry

IS - 37

ER -

COPS5 (Jab1) Protein increases β Site processing of amyloid precursor protein and amyloid βpeptide generation by stabilizing ranbp9 protein levels

Abstract

ASJC Scopus Subject Areas

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