Countering the classical renin-angiotensin system

Natalia M Noto; Yazmin M Restrepo; Robert C Speth; Robert Speth

doi:10.1042/CS20211043

Countering the classical renin-angiotensin system

Natalia M Noto
, Yazmin M Restrepo
, Robert C Speth
, Robert Speth

Nova Southeastern University

Research output: Contribution to journal › Article › peer-review

Abstract

It is well-established that Ang-(1-7) counteracts the effects of Ang II in the periphery, while stimulating vasopressin release and mimicking the activity of Ang II in the brain, through interactions with various receptors. The rapid metabolic inactivation of Ang-(1-7) has proven to be a limitation to therapeutic administration of the peptide. To circumvent this problem, Alves et al. (Clinical Science (2021) 135(18), https://doi.org/10.1042/CS20210599) developed a new transgenic rat model that overexpresses an Ang-(1-7)-producing fusion protein. In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat.

Original language	American English
Journal	Clinical Science
Volume	135
DOIs	https://doi.org/10.1042/CS20211043
State	Published - Dec 10 2021

Keywords

Angiotensin-(1-7)
Cardiovascular System
Renin-Angiotensin System
Sympathetic Nervous System
Transgenic Rat
Vasopressin

Disciplines

Medicine and Health Sciences
Pharmacy and Pharmaceutical Sciences

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10.1042/CS20211043License: Unspecified

https://doi.org/10.1042/CS20211043

Cite this

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title = "Countering the classical renin-angiotensin system",

abstract = " It is well-established that Ang-(1-7) counteracts the effects of Ang II in the periphery, while stimulating vasopressin release and mimicking the activity of Ang II in the brain, through interactions with various receptors. The rapid metabolic inactivation of Ang-(1-7) has proven to be a limitation to therapeutic administration of the peptide. To circumvent this problem, Alves et al. (Clinical Science (2021) 135(18), https://doi.org/10.1042/CS20210599) developed a new transgenic rat model that overexpresses an Ang-(1-7)-producing fusion protein. In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat.",

keywords = "Angiotensin-(1-7), Cardiovascular System, Renin-Angiotensin System, Sympathetic Nervous System, Transgenic Rat, Vasopressin",

author = "Noto, \{Natalia M\} and Restrepo, \{Yazmin M\} and Speth, \{Robert C\} and Robert Speth",

year = "2021",

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doi = "10.1042/CS20211043",

language = "American English",

volume = "135",

journal = "Clinical Science",

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T1 - Countering the classical renin-angiotensin system

AU - Noto, Natalia M

AU - Restrepo, Yazmin M

AU - Speth, Robert C

AU - Speth, Robert

PY - 2021/12/10

Y1 - 2021/12/10

N2 - It is well-established that Ang-(1-7) counteracts the effects of Ang II in the periphery, while stimulating vasopressin release and mimicking the activity of Ang II in the brain, through interactions with various receptors. The rapid metabolic inactivation of Ang-(1-7) has proven to be a limitation to therapeutic administration of the peptide. To circumvent this problem, Alves et al. (Clinical Science (2021) 135(18), https://doi.org/10.1042/CS20210599) developed a new transgenic rat model that overexpresses an Ang-(1-7)-producing fusion protein. In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat.

AB - It is well-established that Ang-(1-7) counteracts the effects of Ang II in the periphery, while stimulating vasopressin release and mimicking the activity of Ang II in the brain, through interactions with various receptors. The rapid metabolic inactivation of Ang-(1-7) has proven to be a limitation to therapeutic administration of the peptide. To circumvent this problem, Alves et al. (Clinical Science (2021) 135(18), https://doi.org/10.1042/CS20210599) developed a new transgenic rat model that overexpresses an Ang-(1-7)-producing fusion protein. In this commentary, we discuss potential concerns with this model while also highlighting advances that can ensue from this significant technical feat.

KW - Angiotensin-(1-7)

KW - Cardiovascular System

KW - Renin-Angiotensin System

KW - Sympathetic Nervous System

KW - Transgenic Rat

KW - Vasopressin

UR - https://nsuworks.nova.edu/hpd_facarticles/42

UR - https://doi.org/10.1042/CS20211043

U2 - 10.1042/CS20211043

DO - 10.1042/CS20211043

M3 - Article

C2 - 34878506

SN - 0143-5221

VL - 135

JO - Clinical Science

JF - Clinical Science

ER -

Countering the classical renin-angiotensin system

Abstract

Keywords

Disciplines

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