Skip to main navigation Skip to search Skip to main content

Doctor says you are cured, but you still feel the pain. Borrelia DNA persistence in Lyme disease

Research output: Contribution to journalShort surveypeer-review

Abstract

Lyme disease is a zoonosis caused by infection with Borrelia burgdorferi (Bb). A great amount of research has attempted to elucidate the mechanisms by which Bb causes inflammation and chronic symptomatology in some patients. Patients often seek unconventional treatments that lack scientific evidence, as medical care is unable to effectively explain and treat their illness. Bb-DNA can persist for long periods of time in some individuals, even after antibiotic therapy. Herein, scientific rationale is presented for a new therapeutic approach against remaining bacterial DNA, and/or increasing the ability of human macrophages to remove extracellular Bb DNA.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalMicrobes and Infection
Volume19
Issue number9-10
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Institut Pasteur

ASJC Scopus Subject Areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Keywords

  • Antimicrobial peptides
  • Borrelia burgdorferi
  • DNA persistence
  • Lyme disease
  • Post-treatment Lyme syndrome
  • TLR9

Fingerprint

Dive into the research topics of 'Doctor says you are cured, but you still feel the pain. Borrelia DNA persistence in Lyme disease'. Together they form a unique fingerprint.

Cite this