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Effect of hypoxia on pig heart short-chain acylcarnitines

  • K. Valkner
  • , S. Ely
  • , J. Kerner
  • , J. Scott
  • , L. L. Bieber

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1.The right ventricles of pig heart were perfused with hypoxic blood and the left ventricles were perfused with normally ventilated arterial blood. 2. 2.Free carnitine and short-chain acylcarnitines in hypoxic ventricles were lower than in perfused controls, and much lower than in non-perfused heart. 3. 3.Acetylcarnitine levels decreased and the branched-chain acylcarnitines and propionylcarnitine were elevated in the hypoxic perfused ventricles. 4. 4.These data indicate that both hypoxia and anaesthesia caused loss of carnitine and short-chain acylcarnitines from the heart and hypoxia also changed the distribution of short-chain acylcarnitines in the heart.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalComparative Biochemistry and Physiology - A: Comparative Physiology
Volume80
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus Subject Areas

  • Physiology

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