Enantioselective Synthesis of 4-and 6-Azaindolines by a Cation-Directed Cyclization

Alan D. Lamb; Peter D. Davey; Russell W. Driver; Amber L. Thompson; Martin D. Smith

doi:10.1021/acs.orglett.6b02744

Enantioselective Synthesis of 4-and 6-Azaindolines by a Cation-Directed Cyclization

Alan D. Lamb
, Peter D. Davey
, Russell W. Driver
, Amber L. Thompson
, Martin D. Smith

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described.

Original language	English
Pages (from-to)	5372-5375
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	20
DOIs	https://doi.org/10.1021/acs.orglett.6b02744
State	Published - Oct 21 2016
Externally published	Yes

Funding

The European Research Council has provided financial support for this work under the European Community’s Seventh Framework Programme (FP7/2007–2013)/ERC Grant Agreement No. 259056. This work was supported by EPSRC (EP/I003398/1). We gratefully acknowledge the Diamond Light Source for an award of instrument time on I19 (MT7768).

Keywords

catalysts
cyclization
materials
molecular structure
stereoselectivity

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10.1021/acs.orglett.6b02744License: CC BY

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AU - Smith, Martin D.

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Enantioselective Synthesis of 4-and 6-Azaindolines by a Cation-Directed Cyclization

Abstract

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