Endothelial cells, cholesterol, cytokines, and aging

S. Tetè; D. Tripodi; M. Rosati; F. Conti; G. Maccauro; A. Saggini; V. Salini; E. Cianchetti; A. Caraffa; P. Antinolfi; E. Toniato; M. L. Castellani; F. Pandolfi; S. Frydas; P. Conti; T. C. Theoharides

doi:10.1177/039463201202500205

Endothelial cells, cholesterol, cytokines, and aging

S. Tetè
, D. Tripodi
, M. Rosati
, F. Conti
, G. Maccauro
, A. Saggini
, V. Salini
, E. Cianchetti
, A. Caraffa
, P. Antinolfi
, E. Toniato
, M. L. Castellani
, F. Pandolfi
, S. Frydas
, P. Conti
, T. C. Theoharides

Research output: Contribution to journal › Review article › peer-review

Abstract

It has been reported that high levels of cholesterol and triglycerides are associated with increased risk of developing atherosclerosis and shorter life. In fact, vascular endothelial dysfunction occurs during the human aging process. Accumulation of lipids in vascular endothelium activates leukocytes to produce cytokines and chemokines which recruit macrophages. On the other hand, macrophages augment inflammatory response and secrete vascular endothelial growth factor, a key cytokine that mediates angiogenesis and inflammatory response. In addition, hyperlipidaemia is one of the main risk factors for aging, hypertension and diabetes. Here, we review the interrelationship between endothelial cells, high level of cholesterol, and aging.

Original language	English
Pages (from-to)	355-363
Number of pages	9
Journal	International Journal of Immunopathology and Pharmacology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1177/039463201202500205
State	Published - 2012
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Pharmacology

Keywords

Cytokine
IL-37
Immunology
Inflammation

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10.1177/039463201202500205

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Tetè, S., Tripodi, D., Rosati, M., Conti, F., Maccauro, G., Saggini, A., Salini, V., Cianchetti, E., Caraffa, A., Antinolfi, P., Toniato, E., Castellani, M. L., Pandolfi, F., Frydas, S., Conti, P., & Theoharides, T. C. (2012). Endothelial cells, cholesterol, cytokines, and aging. International Journal of Immunopathology and Pharmacology, 25(2), 355-363. https://doi.org/10.1177/039463201202500205

Tetè, S, Tripodi, D, Rosati, M, Conti, F, Maccauro, G, Saggini, A, Salini, V, Cianchetti, E, Caraffa, A, Antinolfi, P, Toniato, E, Castellani, ML, Pandolfi, F, Frydas, S, Conti, P & Theoharides, TC 2012, 'Endothelial cells, cholesterol, cytokines, and aging', International Journal of Immunopathology and Pharmacology, vol. 25, no. 2, pp. 355-363. https://doi.org/10.1177/039463201202500205

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title = "Endothelial cells, cholesterol, cytokines, and aging",

abstract = "It has been reported that high levels of cholesterol and triglycerides are associated with increased risk of developing atherosclerosis and shorter life. In fact, vascular endothelial dysfunction occurs during the human aging process. Accumulation of lipids in vascular endothelium activates leukocytes to produce cytokines and chemokines which recruit macrophages. On the other hand, macrophages augment inflammatory response and secrete vascular endothelial growth factor, a key cytokine that mediates angiogenesis and inflammatory response. In addition, hyperlipidaemia is one of the main risk factors for aging, hypertension and diabetes. Here, we review the interrelationship between endothelial cells, high level of cholesterol, and aging.",

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doi = "10.1177/039463201202500205",

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AU - Tetè, S.

AU - Tripodi, D.

AU - Rosati, M.

AU - Conti, F.

AU - Maccauro, G.

AU - Saggini, A.

AU - Salini, V.

AU - Cianchetti, E.

AU - Caraffa, A.

AU - Antinolfi, P.

AU - Toniato, E.

AU - Castellani, M. L.

AU - Pandolfi, F.

AU - Frydas, S.

AU - Conti, P.

AU - Theoharides, T. C.

PY - 2012

Y1 - 2012

N2 - It has been reported that high levels of cholesterol and triglycerides are associated with increased risk of developing atherosclerosis and shorter life. In fact, vascular endothelial dysfunction occurs during the human aging process. Accumulation of lipids in vascular endothelium activates leukocytes to produce cytokines and chemokines which recruit macrophages. On the other hand, macrophages augment inflammatory response and secrete vascular endothelial growth factor, a key cytokine that mediates angiogenesis and inflammatory response. In addition, hyperlipidaemia is one of the main risk factors for aging, hypertension and diabetes. Here, we review the interrelationship between endothelial cells, high level of cholesterol, and aging.

AB - It has been reported that high levels of cholesterol and triglycerides are associated with increased risk of developing atherosclerosis and shorter life. In fact, vascular endothelial dysfunction occurs during the human aging process. Accumulation of lipids in vascular endothelium activates leukocytes to produce cytokines and chemokines which recruit macrophages. On the other hand, macrophages augment inflammatory response and secrete vascular endothelial growth factor, a key cytokine that mediates angiogenesis and inflammatory response. In addition, hyperlipidaemia is one of the main risk factors for aging, hypertension and diabetes. Here, we review the interrelationship between endothelial cells, high level of cholesterol, and aging.

KW - Cytokine

KW - IL-37

KW - Immunology

KW - Inflammation

UR - https://www.scopus.com/pages/publications/84863676903

UR - https://www.scopus.com/pages/publications/84863676903#tab=citedBy

U2 - 10.1177/039463201202500205

DO - 10.1177/039463201202500205

M3 - Review article

AN - SCOPUS:84863676903

SN - 0394-6320

VL - 25

SP - 355

EP - 363

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

IS - 2

ER -

Endothelial cells, cholesterol, cytokines, and aging

Abstract

ASJC Scopus Subject Areas

Keywords

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