Evaluation of the intermittent exotropia questionnaire using rasch analysis

  • Pediatric Eye Disease Investigator Group

Research output: Contribution to journalArticlepeer-review

Abstract

IMPORTANCE: The Intermittent Exotropia Questionnaire (IXTQ) is a patient, proxy, and parental report of quality of life specific to children with intermittent exotropia. We refine the IXTQ using Rasch analysis to improve reliability and validity. OBSERVATION: Rasch analysis was performed on responses of 575 patients with intermittent exotropia enrolled from May 15, 2008, through July 24, 2013, and their parents from each of the 4 IXTQ health-related quality-of-life questionnaires (child 5 through 7 years of age and child 8 through 17 years of age, proxy, and parent questionnaires). Questionnaire performance and structure were confirmed in a separate cohort of 379 patients with intermittent exotropia. One item was removed from the 12-item child and proxy questionnaires, and response options in the 8- to 17-year-old child IXTQ and proxy IXTQ were combined into 3 response options for both questionnaires. Targeting was relatively poor for the child and proxy questionnaires. For the parent questionnaire, 3 subscales (psychosocial, function, and surgery) were evident. One item was removed from the psychosocial subscale. Resulting subscales had appropriate targeting. CONCLUSIONS AND RELEVANCE: The Rasch-revised IXTQ may be a useful instrument for determining how intermittent exotropia affects health-related quality of life of children with intermittent exotropia and their parents, particularly for cohort studies.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalJAMA Ophthalmology
Volume133
Issue number4
DOIs
StatePublished - Apr 1 2015

Bibliographical note

This study was presented in part at the Association for Vision in Research and Ophthalmology Annual Meeting; May 9, 2012; Fort Lauderdale, Florida.

Funding

The study was supported by grants EY018810 (Dr Holmes), EY024333 (Dr Holmes), and EY011751 (Jaeb Center for Health Research) from the National Institutes of Health, Research to Prevent Blindness (Dr Holmes as the Olga Keith Weiss Scholar and an unrestricted grant to the Department of Ophthalmology, Mayo Clinic), and the Mayo Foundation.

ASJC Scopus Subject Areas

  • Ophthalmology

Disciplines

  • Ophthalmology

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