Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation

Charise Dallazem Bertol; Éllen Manica Schonhorst; Natália De Britto Tristacci; Luciana Grazziotin Rossato-Grando; Aline Camilotti Gaio; Samaneh Alaei; Yadollah Omidi; Hamid Omidian

doi:10.1007/s11094-021-02499-6

Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation

Charise Dallazem Bertol
, Éllen Manica Schonhorst
, Natália De Britto Tristacci
, Luciana Grazziotin Rossato-Grando
, Aline Camilotti Gaio
, Samaneh Alaei
, Yadollah Omidi
, Hamid Omidian

Research output: Contribution to journal › Article › peer-review

Abstract

Nitrofurantoin is an old antibiotic currently prescribed to treat urinary tract infections. High dosing frequency causes fluctuations in the drug plasma concentration making less desirable prescription. This work was aimed to overcome these shortcomings by developing extended-release formulations. Tablets were prepared using nitrofurantoin and crosslinked poly(acrylic acid) and hydroxypropyl methylcellulose (HPMC) as hydrophilic polymer matrices. Modified tablets containing HPMC exhibited adequate swelling, erosion, and dissolution profiles and showed potential to decrease the frequency of administrations and reduce fluctuations in the drug plasma concentration. This would result in higher therapeutic effect and increases patient compliance by reducing adverse effects.

Original language	English
Pages (from-to)	808-813
Number of pages	6
Journal	Pharmaceutical Chemistry Journal
Volume	55
Issue number	8
DOIs	https://doi.org/10.1007/s11094-021-02499-6
State	Published - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.

ASJC Scopus Subject Areas

Pharmacology
Drug Discovery

Keywords

carbopol
extended release
hydrophilic matrices
hydroxypropyl methylcellulose
polymer
urinary tract infection

Disciplines

Pharmacology, Toxicology and Environmental Health

Access to Document

10.1007/s11094-021-02499-6

Cite this

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title = "Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation",

abstract = "Nitrofurantoin is an old antibiotic currently prescribed to treat urinary tract infections. High dosing frequency causes fluctuations in the drug plasma concentration making less desirable prescription. This work was aimed to overcome these shortcomings by developing extended-release formulations. Tablets were prepared using nitrofurantoin and crosslinked poly(acrylic acid) and hydroxypropyl methylcellulose (HPMC) as hydrophilic polymer matrices. Modified tablets containing HPMC exhibited adequate swelling, erosion, and dissolution profiles and showed potential to decrease the frequency of administrations and reduce fluctuations in the drug plasma concentration. This would result in higher therapeutic effect and increases patient compliance by reducing adverse effects. ",

keywords = "carbopol, extended release, hydrophilic matrices, hydroxypropyl methylcellulose, polymer, urinary tract infection",

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doi = "10.1007/s11094-021-02499-6",

language = "English",

volume = "55",

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AU - Tristacci, Natália De Britto

AU - Rossato-Grando, Luciana Grazziotin

AU - Gaio, Aline Camilotti

AU - Alaei, Samaneh

AU - Omidi, Yadollah

AU - Omidian, Hamid

PY - 2021/11

Y1 - 2021/11

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KW - carbopol

KW - extended release

KW - hydrophilic matrices

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Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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