Abstract
It has long been suggested that a bidirectional impact exists between periodontitis and diabetes. Periodontitis may affect diabetes glycemic control, insulin resistance, and diabetic complications. Diabetes can worsen periodontitis by delaying wound healing and increasing the chance of infection. Extracellular vesicles (EVs) are heterogeneous particles of membrane-enclosed spherical structure secreted by eukaryotes and prokaryotes and play a key role in a variety of diseases. This review will introduce the biogenesis, release, and biological function of EVs from a microbial and host cell perspective, discuss the functional properties of EVs in the development of periodontitis and diabetes, and explore their role in the pathogenesis and clinical application of these two diseases. Their clinical implication and diagnostic value are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 225-239 |
| Number of pages | 15 |
| Journal | Molecular Oral Microbiology |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2024 |
Bibliographical note
Publisher Copyright:© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ASJC Scopus Subject Areas
- Microbiology
- Immunology
- General Dentistry
- Microbiology (medical)
Keywords
- diabetes
- extracellular vesicles
- inflammatory response
- insulin resistance
- periodontal disease
- vascular dysfunction