Folate receptor-mediated delivery of 1-MDT-loaded mesoporous silica magnetic nanoparticles to target breast cancer cells

Nastaran Hashemzadeh; Mitra Dolatkhah; Ayuob Aghanejad; Mohammad Barzegar-Jalali; Yadollah Omidi; Khosro Adibkia; Jaleh Barar

doi:10.2217/nnm-2021-0176

Folate receptor-mediated delivery of 1-MDT-loaded mesoporous silica magnetic nanoparticles to target breast cancer cells

Nastaran Hashemzadeh
, Mitra Dolatkhah
, Ayuob Aghanejad
, Mohammad Barzegar-Jalali
, Yadollah Omidi
, Khosro Adibkia
, Jaleh Barar

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Aims: The efficiency of mesoporous silica magnetic nanoparticles (MSMNP) as a targeted drug-delivery system was investigated. Methods: The superparamagnetic iron oxide nanoparticles (NP) were synthesized, coated with mesoporous silica and conjugated with polyethylene glycol and methotrexate. Next, 1-methyl-D-tryptophan was loaded into the prepared nanosystems (NS). They were characterized using transmission electron microscopy, scanning electron microscopy, dynamic light scattering, vibrating sample magnetometer, x-ray powder diffraction, Fourier transform-infrared spectroscopy and the Brunauer-Emmett-Teller method and their biological impacts on breast cancer cells were evaluated. Results: The prepared NSs displayed suitable properties and showed enhanced internalization by folate-receptor-expressing cells, exerting efficient cytotoxicity, which was further enhanced by the near-infrared radiation irradiation. Conclusion: On the basis of our findings, the engineered NS is a promising multifunctional nanomedicine/theranostic for solid tumors.

Original language	English
Pages (from-to)	2137-2154
Number of pages	18
Journal	Nanomedicine
Volume	16
Issue number	24
DOIs	https://doi.org/10.2217/nnm-2021-0176
State	Published - Sep 17 2021

Bibliographical note

Publisher Copyright:
© 2021 Future Medicine Ltd.

Funding

This research is a part of PhD thesis (no. 129) and supported by Research Vice-Chancellor of Tabriz University of Medical Sciences (no. 129) and the Research Center for Pharmaceutical Nanotechnology at Tabriz University of Medical Sciences. Y Omidi is a member of the Nanomedicine Editorial Board. They were not involved in any editorial decisions related to the publication of this article, and all author details were blinded to the article’s peer reviewers as per the journal’s double-blind peer review policy. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

ASJC Scopus Subject Areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

Keywords

breast cancer
chemotherapy
d-1-methyl-tryptophan
immunotherapy
indoleamine-2, 3-dioxygenase
targeted therapy
theranostics

Disciplines

Biomedical Engineering and Bioengineering
Materials Science and Engineering
Medicine and Health Sciences

Access to Document

10.2217/nnm-2021-0176

Cite this

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title = "Folate receptor-mediated delivery of 1-MDT-loaded mesoporous silica magnetic nanoparticles to target breast cancer cells",

abstract = "Aims: The efficiency of mesoporous silica magnetic nanoparticles (MSMNP) as a targeted drug-delivery system was investigated. Methods: The superparamagnetic iron oxide nanoparticles (NP) were synthesized, coated with mesoporous silica and conjugated with polyethylene glycol and methotrexate. Next, 1-methyl-D-tryptophan was loaded into the prepared nanosystems (NS). They were characterized using transmission electron microscopy, scanning electron microscopy, dynamic light scattering, vibrating sample magnetometer, x-ray powder diffraction, Fourier transform-infrared spectroscopy and the Brunauer-Emmett-Teller method and their biological impacts on breast cancer cells were evaluated. Results: The prepared NSs displayed suitable properties and showed enhanced internalization by folate-receptor-expressing cells, exerting efficient cytotoxicity, which was further enhanced by the near-infrared radiation irradiation. Conclusion: On the basis of our findings, the engineered NS is a promising multifunctional nanomedicine/theranostic for solid tumors.",

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author = "Nastaran Hashemzadeh and Mitra Dolatkhah and Ayuob Aghanejad and Mohammad Barzegar-Jalali and Yadollah Omidi and Khosro Adibkia and Jaleh Barar",

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doi = "10.2217/nnm-2021-0176",

language = "English",

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AU - Hashemzadeh, Nastaran

AU - Dolatkhah, Mitra

AU - Aghanejad, Ayuob

AU - Barzegar-Jalali, Mohammad

AU - Omidi, Yadollah

AU - Adibkia, Khosro

AU - Barar, Jaleh

PY - 2021/9/17

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AB - Aims: The efficiency of mesoporous silica magnetic nanoparticles (MSMNP) as a targeted drug-delivery system was investigated. Methods: The superparamagnetic iron oxide nanoparticles (NP) were synthesized, coated with mesoporous silica and conjugated with polyethylene glycol and methotrexate. Next, 1-methyl-D-tryptophan was loaded into the prepared nanosystems (NS). They were characterized using transmission electron microscopy, scanning electron microscopy, dynamic light scattering, vibrating sample magnetometer, x-ray powder diffraction, Fourier transform-infrared spectroscopy and the Brunauer-Emmett-Teller method and their biological impacts on breast cancer cells were evaluated. Results: The prepared NSs displayed suitable properties and showed enhanced internalization by folate-receptor-expressing cells, exerting efficient cytotoxicity, which was further enhanced by the near-infrared radiation irradiation. Conclusion: On the basis of our findings, the engineered NS is a promising multifunctional nanomedicine/theranostic for solid tumors.

KW - breast cancer

KW - chemotherapy

KW - d-1-methyl-tryptophan

KW - immunotherapy

KW - indoleamine-2, 3-dioxygenase

KW - targeted therapy

KW - theranostics

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Folate receptor-mediated delivery of 1-MDT-loaded mesoporous silica magnetic nanoparticles to target breast cancer cells

Abstract

Bibliographical note

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Keywords

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