Gastroretentive Drug Delivery System of Carbamazepine: Formulation Optimization Using Simplex Lattice Design: A Technical Note

D M Patel; N M Patel; Naushira Pandya; P D Jogani

doi:10.1208/pt0801011

Gastroretentive Drug Delivery System of Carbamazepine: Formulation Optimization Using Simplex Lattice Design: A Technical Note

D M Patel
, N M Patel
, Naushira Pandya
, P D Jogani

Research output: Contribution to journal › Article › peer-review

Abstract

An attempt was made to develop a gastroretentive drug delivery system of carbamazepine using HPMC, sodium bicarbonate, and EC as matrixing agent, gas-generating agent, and floating enhancer, respectively. A simplex lattice design was applied to investigate the combined effect of 3 formulation variables (ie, amount of HPMC ( X 1), EC ( X 2), and sodium bicarbonate ( X 3). Results of multiple regression analysis indicated that low levels of X 1 and X 2 and a high level of X 3 should be used to manufacture the tablet formulation with desired in vitro floating time and dissolution. Formulation S3 was selected as a promising formulation and was found stable at 40°C temperature and 75% RH for 3 months.

Original language	American English
Pages (from-to)	E82-E86
Journal	AAPS PharmSciTech
Volume	8
Issue number	1
DOIs	https://doi.org/10.1208/pt0801011
State	Published - Mar 2007

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Medicine and Health Sciences
Osteopathic Medicine and Osteopathy

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abstract = "An attempt was made to develop a gastroretentive drug delivery system of carbamazepine using HPMC, sodium bicarbonate, and EC as matrixing agent, gas-generating agent, and floating enhancer, respectively. A simplex lattice design was applied to investigate the combined effect of 3 formulation variables (ie, amount of HPMC ( X 1), EC ( X 2), and sodium bicarbonate ( X 3). Results of multiple regression analysis indicated that low levels of X 1 and X 2 and a high level of X 3 should be used to manufacture the tablet formulation with desired in vitro floating time and dissolution. Formulation S3 was selected as a promising formulation and was found stable at 40°C temperature and 75\% RH for 3 months. ",

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AU - Pandya, Naushira

AU - Jogani, P D

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Gastroretentive Drug Delivery System of Carbamazepine: Formulation Optimization Using Simplex Lattice Design: A Technical Note

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