Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Dipro Bose; Somdatta Chatterjee; Ethan Older; Ratanesh Seth; Patricia Janulewicz; Punnag Saha; Ayan Mondal; Jeffrey M. Carlson; Alan W. Decho; Kimberly Sullivan; Nancy Klimas; Stephen Lasley; Jie Li; Saurabh Chatterjee

doi:10.1038/s42003-022-03494-7

Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Dipro Bose
, Somdatta Chatterjee
, Ethan Older
, Ratanesh Seth
, Patricia Janulewicz
, Punnag Saha
, Ayan Mondal
, Jeffrey M. Carlson
, Alan W. Decho
, Kimberly Sullivan
, Nancy Klimas
, Stephen Lasley
, Jie Li
, Saurabh Chatterjee

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population.

Original language	English
Article number	552
Journal	Communications Biology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/s42003-022-03494-7
State	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

ASJC Scopus Subject Areas

Medicine (miscellaneous)
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1038/s42003-022-03494-7

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Bose, D., Chatterjee, S., Older, E., Seth, R., Janulewicz, P., Saha, P., Mondal, A., Carlson, J. M., Decho, A. W., Sullivan, K., Klimas, N., Lasley, S., Li, J., & Chatterjee, S. (2022). Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation. Communications Biology, 5(1), Article 552. https://doi.org/10.1038/s42003-022-03494-7

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title = "Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation",

abstract = "Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans{\textquoteright} with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population.",

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AU - Bose, Dipro

AU - Chatterjee, Somdatta

AU - Older, Ethan

AU - Seth, Ratanesh

AU - Janulewicz, Patricia

AU - Saha, Punnag

AU - Mondal, Ayan

AU - Carlson, Jeffrey M.

AU - Decho, Alan W.

AU - Sullivan, Kimberly

AU - Klimas, Nancy

AU - Lasley, Stephen

AU - Li, Jie

AU - Chatterjee, Saurabh

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AB - Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population.

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Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Abstract

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