TY - JOUR
T1 - Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation
AU - Bose, Dipro
AU - Chatterjee, Somdatta
AU - Older, Ethan
AU - Seth, Ratanesh
AU - Janulewicz, Patricia
AU - Saha, Punnag
AU - Mondal, Ayan
AU - Carlson, Jeffrey M.
AU - Decho, Alan W.
AU - Sullivan, Kimberly
AU - Klimas, Nancy
AU - Lasley, Stephen
AU - Li, Jie
AU - Chatterjee, Saurabh
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population.
AB - Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population.
UR - https://www.scopus.com/pages/publications/85131486183
UR - https://www.scopus.com/pages/publications/85131486183#tab=citedBy
U2 - 10.1038/s42003-022-03494-7
DO - 10.1038/s42003-022-03494-7
M3 - Article
C2 - 35672382
AN - SCOPUS:85131486183
SN - 2399-3642
VL - 5
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 552
ER -