Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella; Raffaele Favia; Alessandra Giardini; Giordano Lesma; Marisa Martinelli; Alessandra Silvani; Bruno Danieli; Simon M.N. Efange; Deborah C. Mash

doi:10.1016/S0968-0896(02)00524-2

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Daniele Passarella
, Raffaele Favia
, Alessandra Giardini
, Giordano Lesma
, Marisa Martinelli
, Alessandra Silvani
, Bruno Danieli
, Simon M.N. Efange
, Deborah C. Mash

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

Original language	English
Pages (from-to)	1007-1014
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0896(02)00524-2
State	Published - Mar 2003
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0968-0896(02)00524-2

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title = "Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes",

abstract = "Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.",

author = "Daniele Passarella and Raffaele Favia and Alessandra Giardini and Giordano Lesma and Marisa Martinelli and Alessandra Silvani and Bruno Danieli and Efange, \{Simon M.N.\} and Mash, \{Deborah C.\}",

year = "2003",

month = mar,

doi = "10.1016/S0968-0896(02)00524-2",

language = "English",

volume = "11",

pages = "1007--1014",

journal = "Bioorganic and Medicinal Chemistry",

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T1 - Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

AU - Passarella, Daniele

AU - Favia, Raffaele

AU - Giardini, Alessandra

AU - Lesma, Giordano

AU - Martinelli, Marisa

AU - Silvani, Alessandra

AU - Danieli, Bruno

AU - Efange, Simon M.N.

AU - Mash, Deborah C.

PY - 2003/3

Y1 - 2003/3

N2 - Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

AB - Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.

UR - https://www.scopus.com/pages/publications/0037333431

UR - https://www.scopus.com/pages/publications/0037333431#tab=citedBy

U2 - 10.1016/S0968-0896(02)00524-2

DO - 10.1016/S0968-0896(02)00524-2

M3 - Article

C2 - 12614886

AN - SCOPUS:0037333431

SN - 0968-0896

VL - 11

SP - 1007

EP - 1014

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 6

ER -

Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes

Abstract

ASJC Scopus Subject Areas

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