TY - JOUR
T1 - IL-10, an inflammatory/inhibitory cytokine, but not always
AU - Conti, Pio
AU - Kempuraj, Duraisamy
AU - Kandere, Kristiana
AU - Di Gioacchino, Mario
AU - Barbacane, Renato C.
AU - Castellani, Maria L.
AU - Felaco, Mario
AU - Boucher, William
AU - Letourneau, Richard
AU - Theoharides, Theoharis C.
PY - 2003/4/3
Y1 - 2003/4/3
N2 - IL-10 has been previously called cytokine synthesis inhibiting factor, produced mostly by Th2 cells, macrophages and CD8+ cell clones. IL-10 is capable of inhibiting the synthesis of several cytokines from different cells, antigen or mitogen activated. IL-10 exerts its inhibition at the mRNA transcriptional and translational level. In addition, IL-10 is a co-stimulatory cytokine on activated T cells. For example, IL-10 inhibits NK cell activity, the production of Th1 cytokines, cytokines generated by peripheral blood mononuclear cells, and macrophage activity. On the other hand, IL-10 exerts immunostimulatory effects on B cells, cytotoxic T cell development and thymocytes. In mast cells derived from CD4+/CD133+ cells, IL-10 inhibits IL-6 and TNFα, and prostaglandin E1 and E2 induced by IL-6. Here, we report for the first time that IL-10 fails to inhibit tryptase and IL-6 from human mast cell-1 (HMC-1) and human umbilical cord blood-derived mast cells.
AB - IL-10 has been previously called cytokine synthesis inhibiting factor, produced mostly by Th2 cells, macrophages and CD8+ cell clones. IL-10 is capable of inhibiting the synthesis of several cytokines from different cells, antigen or mitogen activated. IL-10 exerts its inhibition at the mRNA transcriptional and translational level. In addition, IL-10 is a co-stimulatory cytokine on activated T cells. For example, IL-10 inhibits NK cell activity, the production of Th1 cytokines, cytokines generated by peripheral blood mononuclear cells, and macrophage activity. On the other hand, IL-10 exerts immunostimulatory effects on B cells, cytotoxic T cell development and thymocytes. In mast cells derived from CD4+/CD133+ cells, IL-10 inhibits IL-6 and TNFα, and prostaglandin E1 and E2 induced by IL-6. Here, we report for the first time that IL-10 fails to inhibit tryptase and IL-6 from human mast cell-1 (HMC-1) and human umbilical cord blood-derived mast cells.
KW - IL-1
KW - IL-6
KW - Immunostimulatory cytokine
KW - Immunosuppressive cytokine
KW - Inflammation
KW - Interleukin-10
KW - Mast cells
KW - Tryptase
UR - https://www.scopus.com/pages/publications/0037417161
UR - https://www.scopus.com/pages/publications/0037417161#tab=citedBy
U2 - 10.1016/S0165-2478(03)00002-6
DO - 10.1016/S0165-2478(03)00002-6
M3 - Review article
C2 - 12644313
AN - SCOPUS:0037417161
SN - 0165-2478
VL - 86
SP - 123
EP - 129
JO - Immunology Letters
JF - Immunology Letters
IS - 2
ER -