IL-31 a TH2 cytokine involved in immunity and inflammation

M. L. Castellani; P. Felaco; R. J. Galzio; D. Tripodi; E. Toniato; M. A. De Lutiis; M. Fulcheri; A. Caraffa; P. Antinolfi; S. Tetè; M. Felaco; F. Conti; F. Pandolfi; T. C. Theoharides; Y. B. Shaik-Dasthagirisaheb

doi:10.1177/039463201002300304

IL-31 a TH2 cytokine involved in immunity and inflammation

M. L. Castellani
, P. Felaco
, R. J. Galzio
, D. Tripodi
, E. Toniato
, M. A. De Lutiis
, M. Fulcheri
, A. Caraffa
, P. Antinolfi
, S. Tetè
, M. Felaco
, F. Conti
, F. Pandolfi
, T. C. Theoharides
, Y. B. Shaik-Dasthagirisaheb

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4⁺ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor. This cytokine is also produced by mast cells and mast cell line, suggesting a role in allergic diseases. In this editorial we revisit the biological role of IL-31 in immunity and inflammation.

Original language	English
Pages (from-to)	709-713
Number of pages	5
Journal	International Journal of Immunopathology and Pharmacology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1177/039463201002300304
State	Published - 2010
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Pharmacology

Keywords

Cytokine
IL-31
Immunity
Inflammation
Interleukin
TH2 cell

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10.1177/039463201002300304

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Castellani, M. L., Felaco, P., Galzio, R. J., Tripodi, D., Toniato, E., De Lutiis, M. A., Fulcheri, M., Caraffa, A., Antinolfi, P., Tetè, S., Felaco, M., Conti, F., Pandolfi, F., Theoharides, T. C., & Shaik-Dasthagirisaheb, Y. B. (2010). IL-31 a TH2 cytokine involved in immunity and inflammation. International Journal of Immunopathology and Pharmacology, 23(3), 709-713. https://doi.org/10.1177/039463201002300304

Castellani, ML, Felaco, P, Galzio, RJ, Tripodi, D, Toniato, E, De Lutiis, MA, Fulcheri, M, Caraffa, A, Antinolfi, P, Tetè, S, Felaco, M, Conti, F, Pandolfi, F, Theoharides, TC & Shaik-Dasthagirisaheb, YB 2010, 'IL-31 a TH2 cytokine involved in immunity and inflammation', International Journal of Immunopathology and Pharmacology, vol. 23, no. 3, pp. 709-713. https://doi.org/10.1177/039463201002300304

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abstract = "Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor. This cytokine is also produced by mast cells and mast cell line, suggesting a role in allergic diseases. In this editorial we revisit the biological role of IL-31 in immunity and inflammation.",

keywords = "Cytokine, IL-31, Immunity, Inflammation, Interleukin, TH2 cell",

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doi = "10.1177/039463201002300304",

language = "English",

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AU - Castellani, M. L.

AU - Felaco, P.

AU - Galzio, R. J.

AU - Tripodi, D.

AU - Toniato, E.

AU - De Lutiis, M. A.

AU - Fulcheri, M.

AU - Caraffa, A.

AU - Antinolfi, P.

AU - Tetè, S.

AU - Felaco, M.

AU - Conti, F.

AU - Pandolfi, F.

AU - Theoharides, T. C.

AU - Shaik-Dasthagirisaheb, Y. B.

PY - 2010

Y1 - 2010

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AB - Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor. This cytokine is also produced by mast cells and mast cell line, suggesting a role in allergic diseases. In this editorial we revisit the biological role of IL-31 in immunity and inflammation.

KW - Cytokine

KW - IL-31

KW - Immunity

KW - Inflammation

KW - Interleukin

KW - TH2 cell

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UR - https://www.scopus.com/pages/publications/78149244832#tab=citedBy

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DO - 10.1177/039463201002300304

M3 - Review article

AN - SCOPUS:78149244832

SN - 0394-6320

VL - 23

SP - 709

EP - 713

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

IS - 3

ER -

IL-31 a TH2 cytokine involved in immunity and inflammation

Abstract

ASJC Scopus Subject Areas

Keywords

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