IL-36 receptor antagonist with special emphasis on IL-38

Y. Shaik; G. Sabatino; G. Maccauro; G. Varvara; G. Murmura; A. Saggini; M. Rosati; F. Conti; E. Cianchetti; A. Caraffa; P. Antinolfi; F. Pandolfi; G. Potalivo; R. Galzio; P. Conti; T. C. Theoharides

doi:10.1177/039463201302600103

IL-36 receptor antagonist with special emphasis on IL-38

Y. Shaik
, G. Sabatino
, G. Maccauro
, G. Varvara
, G. Murmura
, A. Saggini
, M. Rosati
, F. Conti
, E. Cianchetti
, A. Caraffa
, P. Antinolfi
, F. Pandolfi
, G. Potalivo
, R. Galzio
, P. Conti
, T. C. Theoharides

Research output: Contribution to journal › Review article › peer-review

Abstract

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

Original language	English
Pages (from-to)	27-36
Number of pages	10
Journal	International Journal of Immunopathology and Pharmacology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1177/039463201302600103
State	Published - 2013
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Pharmacology

Keywords

Cytokines
IL-36
IL-38
Immunity
Inflammation

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10.1177/039463201302600103

Cite this

Shaik, Y., Sabatino, G., Maccauro, G., Varvara, G., Murmura, G., Saggini, A., Rosati, M., Conti, F., Cianchetti, E., Caraffa, A., Antinolfi, P., Pandolfi, F., Potalivo, G., Galzio, R., Conti, P., & Theoharides, T. C. (2013). IL-36 receptor antagonist with special emphasis on IL-38. International Journal of Immunopathology and Pharmacology, 26(1), 27-36. https://doi.org/10.1177/039463201302600103

Shaik, Y, Sabatino, G, Maccauro, G, Varvara, G, Murmura, G, Saggini, A, Rosati, M, Conti, F, Cianchetti, E, Caraffa, A, Antinolfi, P, Pandolfi, F, Potalivo, G, Galzio, R, Conti, P & Theoharides, TC 2013, 'IL-36 receptor antagonist with special emphasis on IL-38', International Journal of Immunopathology and Pharmacology, vol. 26, no. 1, pp. 27-36. https://doi.org/10.1177/039463201302600103

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title = "IL-36 receptor antagonist with special emphasis on IL-38",

abstract = "IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.",

keywords = "Cytokines, IL-36, IL-38, Immunity, Inflammation",

author = "Y. Shaik and G. Sabatino and G. Maccauro and G. Varvara and G. Murmura and A. Saggini and M. Rosati and F. Conti and E. Cianchetti and A. Caraffa and P. Antinolfi and F. Pandolfi and G. Potalivo and R. Galzio and P. Conti and Theoharides, \{T. C.\}",

year = "2013",

doi = "10.1177/039463201302600103",

language = "English",

volume = "26",

pages = "27--36",

journal = "International Journal of Immunopathology and Pharmacology",

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T1 - IL-36 receptor antagonist with special emphasis on IL-38

AU - Shaik, Y.

AU - Sabatino, G.

AU - Maccauro, G.

AU - Varvara, G.

AU - Murmura, G.

AU - Saggini, A.

AU - Rosati, M.

AU - Conti, F.

AU - Cianchetti, E.

AU - Caraffa, A.

AU - Antinolfi, P.

AU - Pandolfi, F.

AU - Potalivo, G.

AU - Galzio, R.

AU - Conti, P.

AU - Theoharides, T. C.

PY - 2013

Y1 - 2013

N2 - IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

AB - IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

KW - Cytokines

KW - IL-36

KW - IL-38

KW - Immunity

KW - Inflammation

UR - https://www.scopus.com/pages/publications/84881248182

UR - https://www.scopus.com/pages/publications/84881248182#tab=citedBy

U2 - 10.1177/039463201302600103

DO - 10.1177/039463201302600103

M3 - Review article

C2 - 23527706

AN - SCOPUS:84881248182

SN - 0394-6320

VL - 26

SP - 27

EP - 36

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

IS - 1

ER -

IL-36 receptor antagonist with special emphasis on IL-38

Abstract

ASJC Scopus Subject Areas

Keywords

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