IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation

S. Tetè; D. Tripodi; M. Rosati; F. Conti; G. Maccauro; A. Saggini; E. Cianchetti; A. Caraffa; P. Antinolfi; E. Toniato; M. L. Castellani; P. Conti; T. C. Theoharides

doi:10.1177/039463201202500105

IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation

S. Tetè
, D. Tripodi
, M. Rosati
, F. Conti
, G. Maccauro
, A. Saggini
, E. Cianchetti
, A. Caraffa
, P. Antinolfi
, E. Toniato
, M. L. Castellani
, P. Conti
, T. C. Theoharides

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, production and function of proinflammatory cytokines: IL-1 family pro-inflammatory effects are markedly suppressed by IL-37.

Original language	English
Pages (from-to)	31-38
Number of pages	8
Journal	International Journal of Immunopathology and Pharmacology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1177/039463201202500105
State	Published - 2012
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Pharmacology

Keywords

Cytokine
IL-37
Immunology
Inflammation

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10.1177/039463201202500105

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Tetè, S., Tripodi, D., Rosati, M., Conti, F., Maccauro, G., Saggini, A., Cianchetti, E., Caraffa, A., Antinolfi, P., Toniato, E., Castellani, M. L., Conti, P., & Theoharides, T. C. (2012). IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation. International Journal of Immunopathology and Pharmacology, 25(1), 31-38. https://doi.org/10.1177/039463201202500105

Tetè, S, Tripodi, D, Rosati, M, Conti, F, Maccauro, G, Saggini, A, Cianchetti, E, Caraffa, A, Antinolfi, P, Toniato, E, Castellani, ML, Conti, P & Theoharides, TC 2012, 'IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation', International Journal of Immunopathology and Pharmacology, vol. 25, no. 1, pp. 31-38. https://doi.org/10.1177/039463201202500105

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abstract = "Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, production and function of proinflammatory cytokines: IL-1 family pro-inflammatory effects are markedly suppressed by IL-37.",

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doi = "10.1177/039463201202500105",

language = "English",

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AU - Tetè, S.

AU - Tripodi, D.

AU - Rosati, M.

AU - Conti, F.

AU - Maccauro, G.

AU - Saggini, A.

AU - Cianchetti, E.

AU - Caraffa, A.

AU - Antinolfi, P.

AU - Toniato, E.

AU - Castellani, M. L.

AU - Conti, P.

AU - Theoharides, T. C.

PY - 2012

Y1 - 2012

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AB - Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, production and function of proinflammatory cytokines: IL-1 family pro-inflammatory effects are markedly suppressed by IL-37.

KW - Cytokine

KW - IL-37

KW - Immunology

KW - Inflammation

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SN - 0394-6320

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IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation

Abstract

ASJC Scopus Subject Areas

Keywords

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