Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog

Jeannine H. Powell; Edward M. Johnson; Peter M. Gannett

doi:10.3390/51201244

Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog

Jeannine H. Powell
, Edward M. Johnson
, Peter M. Gannett

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5- tetramethyl-pyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.

Original language	English
Pages (from-to)	1244-1250
Number of pages	7
Journal	Molecules
Volume	5
Issue number	12
DOIs	https://doi.org/10.3390/51201244
State	Published - Dec 2000
Externally published	Yes

ASJC Scopus Subject Areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Keywords

Alcohol
Anhydride
Carboxylic acid
Nitroxide
Reduction
Spin label

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10.3390/51201244

Cite this

@article{741797168c05402ab8463db694df0007,

title = "Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog",

abstract = "Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5- tetramethyl-pyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed. ",

keywords = "Alcohol, Anhydride, Carboxylic acid, Nitroxide, Reduction, Spin label",

author = "Powell, \{Jeannine H.\} and Johnson, \{Edward M.\} and Gannett, \{Peter M.\}",

year = "2000",

month = dec,

doi = "10.3390/51201244",

language = "English",

volume = "5",

pages = "1244--1250",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog

AU - Powell, Jeannine H.

AU - Johnson, Edward M.

AU - Gannett, Peter M.

PY - 2000/12

Y1 - 2000/12

N2 - Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5- tetramethyl-pyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.

AB - Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5- tetramethyl-pyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.

KW - Alcohol

KW - Anhydride

KW - Carboxylic acid

KW - Nitroxide

KW - Reduction

KW - Spin label

UR - https://www.scopus.com/pages/publications/3342956450

UR - https://www.scopus.com/pages/publications/3342956450#tab=citedBy

U2 - 10.3390/51201244

DO - 10.3390/51201244

M3 - Article

AN - SCOPUS:3342956450

SN - 1420-3049

VL - 5

SP - 1244

EP - 1250

JO - Molecules

JF - Molecules

IS - 12

ER -

Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog

Abstract

ASJC Scopus Subject Areas

Keywords

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