Interleukin-17 and the interleukin-17 family member network

Shu Hai Huang; Stavros Frydas; Duraisamy Kempuraj; Renato C. Barbacane; Alfredo Grilli; William Boucher; Richard Letourneau; Bhuvaneshwari Madhappan; Nikoletta Papadopoulou; Nicola Verna; Maria Anna De Lutiis; Teresa Iezzi; Graziano Riccioni; Theoharis C. Theoharides; Pio Conti

Research output: Contribution to journal › Review article › peer-review

Abstract

Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4⁺ activated memory T cells (CD45 ⁺RO⁺) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.

Original language	English
Pages (from-to)	17-21
Number of pages	5
Journal	Allergy and Asthma Proceedings
Volume	25
Issue number	1
State	Published - Jan 2004
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Pulmonary and Respiratory Medicine

Cite this

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title = "Interleukin-17 and the interleukin-17 family member network",

abstract = "Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45 +RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58\% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.",

author = "Huang, \{Shu Hai\} and Stavros Frydas and Duraisamy Kempuraj and Barbacane, \{Renato C.\} and Alfredo Grilli and William Boucher and Richard Letourneau and Bhuvaneshwari Madhappan and Nikoletta Papadopoulou and Nicola Verna and \{De Lutiis\}, \{Maria Anna\} and Teresa Iezzi and Graziano Riccioni and Theoharides, \{Theoharis C.\} and Pio Conti",

year = "2004",

month = jan,

language = "English",

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journal = "Allergy and Asthma Proceedings",

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TY - JOUR

T1 - Interleukin-17 and the interleukin-17 family member network

AU - Huang, Shu Hai

AU - Frydas, Stavros

AU - Kempuraj, Duraisamy

AU - Barbacane, Renato C.

AU - Grilli, Alfredo

AU - Boucher, William

AU - Letourneau, Richard

AU - Madhappan, Bhuvaneshwari

AU - Papadopoulou, Nikoletta

AU - Verna, Nicola

AU - De Lutiis, Maria Anna

AU - Iezzi, Teresa

AU - Riccioni, Graziano

AU - Theoharides, Theoharis C.

AU - Conti, Pio

PY - 2004/1

Y1 - 2004/1

N2 - Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45 +RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.

AB - Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45 +RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.

UR - https://www.scopus.com/pages/publications/12144285843

UR - https://www.scopus.com/pages/publications/12144285843#tab=citedBy

M3 - Review article

C2 - 15055556

AN - SCOPUS:12144285843

SN - 1088-5412

VL - 25

SP - 17

EP - 21

JO - Allergy and Asthma Proceedings

JF - Allergy and Asthma Proceedings

IS - 1

ER -

Interleukin-17 and the interleukin-17 family member network

Abstract

ASJC Scopus Subject Areas

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