Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N′-diethylaminoethyl methacrylate)

Jong-Sang Park; Yong-Beom Lim; Young-Min Kwon; Byeongmoon Jeong; Young Hun Choi; Sung Wan Kim

doi:10.1002/(SICI)1099-0518(19990715)37:14

Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N′-diethylaminoethyl methacrylate)

Jong-Sang Park
, Yong-Beom Lim
, Young-Min Kwon
, Byeongmoon Jeong
, Young Hun Choi
, Sung Wan Kim

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Copolymers of 4-vinylpyridine (4VP) or N,N?-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pH-dependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pKa value of the two monomers. ? 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2305?2309, 1999

Original language	American English
Pages (from-to)	2305-2309
Number of pages	5
Journal	Journal of Polymer Science Part A: Polymer Chemistry
Volume	37
Issue number	14
DOIs	https://doi.org/10.1002/(SICI)1099-0518(19990715)37:14
State	Published - 1999
Externally published	Yes

Keywords

pH-sensitive polymer
membrane fusion
liposome
resonance energy transfer

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10.1002/(SICI)1099-0518(19990715)37:14

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@article{58125d26a9ef410fa03b54fdf5ca3d05,

title = "Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N′-diethylaminoethyl methacrylate)",

abstract = "Abstract Copolymers of 4-vinylpyridine (4VP) or N,N?-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pH-dependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pKa value of the two monomers. ? 1999 John Wiley \& Sons, Inc. J Polym Sci A: Polym Chem 37: 2305?2309, 1999",

keywords = "pH-sensitive polymer, membrane fusion, liposome, resonance energy transfer",

author = "Jong-Sang Park and Yong-Beom Lim and Young-Min Kwon and Byeongmoon Jeong and Choi, \{Young Hun\} and Kim, \{Sung Wan\}",

year = "1999",

doi = "10.1002/(SICI)1099-0518(19990715)37:14",

language = "American English",

volume = "37",

pages = "2305--2309",

journal = "Journal of Polymer Science Part A: Polymer Chemistry",

issn = "0887-624X",

publisher = "John Wiley \& Sons Inc.",

number = "14",

}

TY - JOUR

T1 - Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N′-diethylaminoethyl methacrylate)

AU - Park, Jong-Sang

AU - Lim, Yong-Beom

AU - Kwon, Young-Min

AU - Jeong, Byeongmoon

AU - Choi, Young Hun

AU - Kim, Sung Wan

PY - 1999

Y1 - 1999

N2 - Abstract Copolymers of 4-vinylpyridine (4VP) or N,N?-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pH-dependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pKa value of the two monomers. ? 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2305?2309, 1999

AB - Abstract Copolymers of 4-vinylpyridine (4VP) or N,N?-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pH-dependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pKa value of the two monomers. ? 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2305?2309, 1999

KW - pH-sensitive polymer

KW - membrane fusion

KW - liposome

KW - resonance energy transfer

U2 - 10.1002/(SICI)1099-0518(19990715)37:14

DO - 10.1002/(SICI)1099-0518(19990715)37:14

M3 - Article

SN - 0887-624X

VL - 37

SP - 2305

EP - 2309

JO - Journal of Polymer Science Part A: Polymer Chemistry

JF - Journal of Polymer Science Part A: Polymer Chemistry

IS - 14

ER -

Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N′-diethylaminoethyl methacrylate)

Abstract

Keywords

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