Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism

Yahya M. Al-Farsi; Mostafa I. Waly; Richard C. Deth; Marwan M. Al-Sharbati; Mohamed Al-Shafaee; Omar Al-Farsi; Maha M. Al-Khaduri; Ishita Gupta; Amanat Ali; Maha Al-Khalili; Samir Al-Adawi; Nathaniel W. Hodgson; Allal Ouhtit

doi:10.1016/j.nut.2012.09.014

Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism

Yahya M. Al-Farsi
, Mostafa I. Waly
, Richard C. Deth
, Marwan M. Al-Sharbati
, Mohamed Al-Shafaee
, Omar Al-Farsi
, Maha M. Al-Khaduri
, Ishita Gupta
, Amanat Ali
, Maha Al-Khalili
, Samir Al-Adawi
, Nathaniel W. Hodgson
, Allal Ouhtit

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies.

Original language	English
Pages (from-to)	537-541
Number of pages	5
Journal	Nutrition
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.nut.2012.09.014
State	Published - Mar 2013
Externally published	Yes

Bibliographical note

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Keywords

Autism
Folate
Methylation
Nutrition
Oman
Vitamin B12
Folic Acid Deficiency/complications
Humans
Child, Preschool
Vitamin B 12/administration & dosage
Male
Autistic Disorder/complications
Case-Control Studies
Nutrition Assessment
Oman/epidemiology
Diet
Folic Acid/administration & dosage
Vitamin B 12 Deficiency/complications
Female
Homocysteine/blood
Nutritional Status
Odds Ratio

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10.1016/j.nut.2012.09.014

Cite this

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title = "Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism",

abstract = "Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies. ",

keywords = "Autism, Folate, Methylation, Nutrition, Oman, Vitamin B12, Folic Acid Deficiency/complications, Humans, Child, Preschool, Vitamin B 12/administration \& dosage, Male, Autistic Disorder/complications, Case-Control Studies, Nutrition Assessment, Oman/epidemiology, Diet, Folic Acid/administration \& dosage, Vitamin B 12 Deficiency/complications, Female, Homocysteine/blood, Nutritional Status, Odds Ratio",

author = "Al-Farsi, \{Yahya M.\} and Waly, \{Mostafa I.\} and Deth, \{Richard C.\} and Al-Sharbati, \{Marwan M.\} and Mohamed Al-Shafaee and Omar Al-Farsi and Al-Khaduri, \{Maha M.\} and Ishita Gupta and Amanat Ali and Maha Al-Khalili and Samir Al-Adawi and Hodgson, \{Nathaniel W.\} and Allal Ouhtit",

year = "2013",

month = mar,

doi = "10.1016/j.nut.2012.09.014",

language = "English",

volume = "29",

pages = "537--541",

journal = "Nutrition",

issn = "0899-9007",

publisher = "Elsevier Inc.",

number = "3",

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TY - JOUR

T1 - Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism

AU - Al-Farsi, Yahya M.

AU - Waly, Mostafa I.

AU - Deth, Richard C.

AU - Al-Sharbati, Marwan M.

AU - Al-Shafaee, Mohamed

AU - Al-Farsi, Omar

AU - Al-Khaduri, Maha M.

AU - Gupta, Ishita

AU - Ali, Amanat

AU - Al-Khalili, Maha

AU - Al-Adawi, Samir

AU - Hodgson, Nathaniel W.

AU - Ouhtit, Allal

PY - 2013/3

Y1 - 2013/3

N2 - Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies.

AB - Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies.

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KW - Diet

KW - Folic Acid/administration & dosage

KW - Vitamin B 12 Deficiency/complications

KW - Female

KW - Homocysteine/blood

KW - Nutritional Status

KW - Odds Ratio

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Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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