MELAS and reversible vasoconstriction of the major cerebral arteries

Takeshi Yoshida; Atsushi Ouchi; Daisuke Miura; Kunihiro Shimoji; Kazushi Kinjo; Takeshi Sueyoshi; Manabu Jonosono; Vijay Rajput

doi:10.2169/internalmedicine.52.0188

MELAS and reversible vasoconstriction of the major cerebral arteries

Takeshi Yoshida
, Atsushi Ouchi
, Daisuke Miura
, Kunihiro Shimoji
, Kazushi Kinjo
, Takeshi Sueyoshi
, Manabu Jonosono
, Vijay Rajput

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A 26-year-old woman was admitted due to an altered mental status and generalized tonic-clonic seizures. She had experienced chronic migraine-like headaches, progressive bilateral hearing loss, a short stature and nephrotic syndrome. Laboratory data showed elevated lactate and pyruvate levels. Brain MRI using diffusionweighted imaging revealed a hyperintense lesion in the left temporal lobe. MR angiography revealed segmental stenosis at the C1 and M1-2 junction. A genetic study revealed a mitochondrial DNA A3243G point mutation. The patient's clinical symptoms and MRI/MR angiography (MRA) findings improved within four weeks. We herein discuss the possible pathophysiology involving both stroke-like episodes and reversible vasoconstriction.

Original language	English
Pages (from-to)	1389-1392
Number of pages	4
Journal	Internal Medicine
Volume	52
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.52.0188
State	Published - 2013
Externally published	Yes

ASJC Scopus Subject Areas

Internal Medicine

Keywords

L-arginine
Lactic acidosis
Mitochondrial encephalopathy
Reversible cerebral vasoconstriction syndrome
Stroke-like episode

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10.2169/internalmedicine.52.0188

Cite this

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abstract = "A 26-year-old woman was admitted due to an altered mental status and generalized tonic-clonic seizures. She had experienced chronic migraine-like headaches, progressive bilateral hearing loss, a short stature and nephrotic syndrome. Laboratory data showed elevated lactate and pyruvate levels. Brain MRI using diffusionweighted imaging revealed a hyperintense lesion in the left temporal lobe. MR angiography revealed segmental stenosis at the C1 and M1-2 junction. A genetic study revealed a mitochondrial DNA A3243G point mutation. The patient's clinical symptoms and MRI/MR angiography (MRA) findings improved within four weeks. We herein discuss the possible pathophysiology involving both stroke-like episodes and reversible vasoconstriction.",

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AU - Yoshida, Takeshi

AU - Ouchi, Atsushi

AU - Miura, Daisuke

AU - Shimoji, Kunihiro

AU - Kinjo, Kazushi

AU - Sueyoshi, Takeshi

AU - Jonosono, Manabu

AU - Rajput, Vijay

PY - 2013

Y1 - 2013

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AB - A 26-year-old woman was admitted due to an altered mental status and generalized tonic-clonic seizures. She had experienced chronic migraine-like headaches, progressive bilateral hearing loss, a short stature and nephrotic syndrome. Laboratory data showed elevated lactate and pyruvate levels. Brain MRI using diffusionweighted imaging revealed a hyperintense lesion in the left temporal lobe. MR angiography revealed segmental stenosis at the C1 and M1-2 junction. A genetic study revealed a mitochondrial DNA A3243G point mutation. The patient's clinical symptoms and MRI/MR angiography (MRA) findings improved within four weeks. We herein discuss the possible pathophysiology involving both stroke-like episodes and reversible vasoconstriction.

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KW - Lactic acidosis

KW - Mitochondrial encephalopathy

KW - Reversible cerebral vasoconstriction syndrome

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MELAS and reversible vasoconstriction of the major cerebral arteries

Abstract

ASJC Scopus Subject Areas

Keywords

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