Microvascular hemodynamic variations accompanying microvessel dimensional changes

The bat wing is used as an experimental preparation and as a self-contained vascular bed. The number, dimensions, and distribution of the vessels of the real vascular bed are included into an analyzable, representative geometric configuration. Based on theoretical analysis and experimental data, equations are developed and utilized to characterize the pressure-flow relationships for each branching order of the vascular field. The geometric configuration and associated describing equations are used to determine the effects of microvessel diameter change on the distribution of resistance, pressure, and velocity throughout the microvasculature. Predicted hemodynamic changes are compared with available experimental data and evaluated in the light of current concepts concerning the significance of microvessel dimensional changes.