Molecular impacts of advanced nanomaterials at genomic and epigenomic levels

Kamran Shekh; Rais A. Ansari; Yadollah Omidi; Saghir A. Shakil

doi:10.1002/9781119896258.ch2

Molecular impacts of advanced nanomaterials at genomic and epigenomic levels

Kamran Shekh
, Rais A. Ansari
, Yadollah Omidi
, Saghir A. Shakil

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The use of nanomaterials has significantly increased in the past few decades owing to their unique physicochemical properties that differ vastly from their bulk forms. Such specific physicochemical characteristics are also responsible for their distinctive biological and toxicological effects. Various organic and inorganic nanomaterials have been used for pharmaceutical/biomedical purposes. Many of the biological and toxicological effects elicited by nanomaterials are due to their ability in interacting with biological entities at molecular levels such as genetic and epigenetic effects. This chapter aims to provide an overview of the known genetic and epigenetic effects induced by major nanomaterials.

Original language	English
Title of host publication	Impact of Engineered Nanomaterials in Genomics and Epigenomics
Editors	Saura C. Sahu
Publisher	Wiley-Blackwell
Chapter	2
Pages	5-39
Number of pages	35
ISBN (Electronic)	9781119896258
ISBN (Print)	9781119896227
DOIs	https://doi.org/10.1002/9781119896258.ch2
State	Published - May 15 2023

Bibliographical note

Publisher Copyright:
© 2023 John Wiley & Sons Ltd.

ASJC Scopus Subject Areas

General Chemistry
General Chemical Engineering

Keywords

Cellular uptake
Deacetylation
Environmental health
Epigenetics
Genotoxicity
Methylation
Nanomaterials
Noncoding RNA
Toxicity
Toxicogenomics

Disciplines

Chemistry
Chemical Engineering

Access to Document

10.1002/9781119896258.ch2

Cite this

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title = "Molecular impacts of advanced nanomaterials at genomic and epigenomic levels",

abstract = "The use of nanomaterials has significantly increased in the past few decades owing to their unique physicochemical properties that differ vastly from their bulk forms. Such specific physicochemical characteristics are also responsible for their distinctive biological and toxicological effects. Various organic and inorganic nanomaterials have been used for pharmaceutical/biomedical purposes. Many of the biological and toxicological effects elicited by nanomaterials are due to their ability in interacting with biological entities at molecular levels such as genetic and epigenetic effects. This chapter aims to provide an overview of the known genetic and epigenetic effects induced by major nanomaterials.",

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language = "English",

isbn = "9781119896227",

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TY - CHAP

T1 - Molecular impacts of advanced nanomaterials at genomic and epigenomic levels

AU - Shekh, Kamran

AU - Ansari, Rais A.

AU - Omidi, Yadollah

AU - Shakil, Saghir A.

PY - 2023/5/15

Y1 - 2023/5/15

N2 - The use of nanomaterials has significantly increased in the past few decades owing to their unique physicochemical properties that differ vastly from their bulk forms. Such specific physicochemical characteristics are also responsible for their distinctive biological and toxicological effects. Various organic and inorganic nanomaterials have been used for pharmaceutical/biomedical purposes. Many of the biological and toxicological effects elicited by nanomaterials are due to their ability in interacting with biological entities at molecular levels such as genetic and epigenetic effects. This chapter aims to provide an overview of the known genetic and epigenetic effects induced by major nanomaterials.

AB - The use of nanomaterials has significantly increased in the past few decades owing to their unique physicochemical properties that differ vastly from their bulk forms. Such specific physicochemical characteristics are also responsible for their distinctive biological and toxicological effects. Various organic and inorganic nanomaterials have been used for pharmaceutical/biomedical purposes. Many of the biological and toxicological effects elicited by nanomaterials are due to their ability in interacting with biological entities at molecular levels such as genetic and epigenetic effects. This chapter aims to provide an overview of the known genetic and epigenetic effects induced by major nanomaterials.

KW - Cellular uptake

KW - Deacetylation

KW - Environmental health

KW - Epigenetics

KW - Genotoxicity

KW - Methylation

KW - Nanomaterials

KW - Noncoding RNA

KW - Toxicity

KW - Toxicogenomics

UR - https://www.scopus.com/pages/publications/85160974129

UR - https://www.scopus.com/pages/publications/85160974129#tab=citedBy

U2 - 10.1002/9781119896258.ch2

DO - 10.1002/9781119896258.ch2

M3 - Chapter

AN - SCOPUS:85160974129

SN - 9781119896227

SP - 5

EP - 39

BT - Impact of Engineered Nanomaterials in Genomics and Epigenomics

A2 - Sahu, Saura C.

PB - Wiley-Blackwell

ER -

Molecular impacts of advanced nanomaterials at genomic and epigenomic levels

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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Endocrine disruptors: Genetic, epigenetic, and related pathways

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