Abstract
Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.
| Original language | English |
|---|---|
| Article number | 168 |
| Journal | Journal of neuroinflammation |
| Volume | 8 |
| DOIs | |
| State | Published - Nov 30 2011 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- General Neuroscience
- Immunology
- Neurology
- Cellular and Molecular Neuroscience
Keywords
- Autism
- Blood-brain barrier
- Flavonoids
- Mast cells
- Neuroinflammation