Neuroendocrinology of the skin

Theoharis C. Theoharides; Julia M. Stewart; Alexandra Taracanova; Pio Conti; Christos C. Zouboulis

doi:10.1007/s11154-016-9369-9

Neuroendocrinology of the skin

Theoharis C. Theoharides
, Julia M. Stewart
, Alexandra Taracanova
, Pio Conti
, Christos C. Zouboulis

Research output: Contribution to journal › Review article › peer-review

Abstract

The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local “hypothalamic-pituitary-adrenal axis.” In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

Original language	English
Pages (from-to)	287-294
Number of pages	8
Journal	Reviews in Endocrine and Metabolic Disorders
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/s11154-016-9369-9
State	Published - Sep 1 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Keywords

Corticotropin-releasing hormone
Hypothalamic-pituitary-adrenal axis
Neuroendocrinology
Neurotensin
Skin

Access to Document

10.1007/s11154-016-9369-9

Cite this

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title = "Neuroendocrinology of the skin",

abstract = "The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local “hypothalamic-pituitary-adrenal axis.” In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.",

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AU - Stewart, Julia M.

AU - Taracanova, Alexandra

AU - Conti, Pio

AU - Zouboulis, Christos C.

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KW - Hypothalamic-pituitary-adrenal axis

KW - Neuroendocrinology

KW - Neurotensin

KW - Skin

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Neuroendocrinology of the skin

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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