Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study

Melissa A. Friedman; Patricia Arena; Bonnie Levin; Lora Fleming; Mercedes Fernandez; Richard Weisman; Jeff Bernstein; Kathleen Schrank; Donna Blythe; Lorraine Backer; Andrew Reich

doi:10.1016/j.acn.2007.03.003

Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study

Melissa A. Friedman
, Patricia Arena
, Bonnie Levin
, Lora Fleming
, Mercedes Fernandez
, Richard Weisman
, Jeff Bernstein
, Kathleen Schrank
, Donna Blythe
, Lorraine Backer
, Andrew Reich

College of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP).

METHOD:

In a longitudinal matched cohort study, 12 CFP cases and 12 matched friend-controls received baseline neuropsychological evaluations within one month after intoxication and follow-up evaluations approximately six months after baseline.

RESULTS:

Only one case received intravenous mannitol treatment, which occurred 10 or more days after intoxication. At baseline and follow-up evaluations, there were no statistically significant differences between CFP cases and controls on cognitive measures. At baseline, however, CFP cases endorsed significantly greater subjective toxicity symptoms (e.g. fatigue, tingling sensations) and greater anxiety symptoms than controls. Follow-up evaluations suggested resolution of all symptoms after six months. Subsequent analyses, in which data from this study were pooled with data from an earlier pilot study, supported these results.

CONCLUSION:

Untreated ciguatera was associated acutely with significant subjective neurotoxicity symptoms and anxiety which were transient, but not with objectively measured cognitive changes. Future investigation with a larger sample size is warranted

Original language	American English
Journal	Archives of Clinical Neuropsychology
Volume	22
DOIs	https://doi.org/10.1016/j.acn.2007.03.003
State	Published - May 1 2007

Keywords

ciguatera
cognition
harmful algae blooms (HABs)
neurobehavioral
neuropsychology
neurotoxins
toxins

Disciplines

Psychology

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@article{ddf0d0493128454aa226340e4287ae2c,

title = "Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study",

abstract = " The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP). METHOD: In a longitudinal matched cohort study, 12 CFP cases and 12 matched friend-controls received baseline neuropsychological evaluations within one month after intoxication and follow-up evaluations approximately six months after baseline. RESULTS: Only one case received intravenous mannitol treatment, which occurred 10 or more days after intoxication. At baseline and follow-up evaluations, there were no statistically significant differences between CFP cases and controls on cognitive measures. At baseline, however, CFP cases endorsed significantly greater subjective toxicity symptoms (e.g. fatigue, tingling sensations) and greater anxiety symptoms than controls. Follow-up evaluations suggested resolution of all symptoms after six months. Subsequent analyses, in which data from this study were pooled with data from an earlier pilot study, supported these results. CONCLUSION: Untreated ciguatera was associated acutely with significant subjective neurotoxicity symptoms and anxiety which were transient, but not with objectively measured cognitive changes. Future investigation with a larger sample size is warranted",

keywords = "ciguatera, cognition, harmful algae blooms (HABs), neurobehavioral, neuropsychology, neurotoxins, toxins",

author = "Friedman, \{Melissa A.\} and Patricia Arena and Bonnie Levin and Lora Fleming and Mercedes Fernandez and Richard Weisman and Jeff Bernstein and Kathleen Schrank and Donna Blythe and Lorraine Backer and Andrew Reich",

year = "2007",

month = may,

day = "1",

doi = "10.1016/j.acn.2007.03.003",

language = "American English",

volume = "22",

journal = "Archives of Clinical Neuropsychology",

issn = "0887-6177",

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TY - JOUR

T1 - Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study

AU - Friedman, Melissa A.

AU - Arena, Patricia

AU - Levin, Bonnie

AU - Fleming, Lora

AU - Fernandez, Mercedes

AU - Weisman, Richard

AU - Bernstein, Jeff

AU - Schrank, Kathleen

AU - Blythe, Donna

AU - Backer, Lorraine

AU - Reich, Andrew

PY - 2007/5/1

Y1 - 2007/5/1

N2 - The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP). METHOD: In a longitudinal matched cohort study, 12 CFP cases and 12 matched friend-controls received baseline neuropsychological evaluations within one month after intoxication and follow-up evaluations approximately six months after baseline. RESULTS: Only one case received intravenous mannitol treatment, which occurred 10 or more days after intoxication. At baseline and follow-up evaluations, there were no statistically significant differences between CFP cases and controls on cognitive measures. At baseline, however, CFP cases endorsed significantly greater subjective toxicity symptoms (e.g. fatigue, tingling sensations) and greater anxiety symptoms than controls. Follow-up evaluations suggested resolution of all symptoms after six months. Subsequent analyses, in which data from this study were pooled with data from an earlier pilot study, supported these results. CONCLUSION: Untreated ciguatera was associated acutely with significant subjective neurotoxicity symptoms and anxiety which were transient, but not with objectively measured cognitive changes. Future investigation with a larger sample size is warranted

AB - The purpose of the study was to evaluate the neuropsychological effects of ciguatera fish poisoning (CFP). METHOD: In a longitudinal matched cohort study, 12 CFP cases and 12 matched friend-controls received baseline neuropsychological evaluations within one month after intoxication and follow-up evaluations approximately six months after baseline. RESULTS: Only one case received intravenous mannitol treatment, which occurred 10 or more days after intoxication. At baseline and follow-up evaluations, there were no statistically significant differences between CFP cases and controls on cognitive measures. At baseline, however, CFP cases endorsed significantly greater subjective toxicity symptoms (e.g. fatigue, tingling sensations) and greater anxiety symptoms than controls. Follow-up evaluations suggested resolution of all symptoms after six months. Subsequent analyses, in which data from this study were pooled with data from an earlier pilot study, supported these results. CONCLUSION: Untreated ciguatera was associated acutely with significant subjective neurotoxicity symptoms and anxiety which were transient, but not with objectively measured cognitive changes. Future investigation with a larger sample size is warranted

KW - ciguatera

KW - cognition

KW - harmful algae blooms (HABs)

KW - neurobehavioral

KW - neuropsychology

KW - neurotoxins

KW - toxins

UR - https://nsuworks.nova.edu/cps_facarticles/1084

U2 - 10.1016/j.acn.2007.03.003

DO - 10.1016/j.acn.2007.03.003

M3 - Article

C2 - 17482422

SN - 0887-6177

VL - 22

JO - Archives of Clinical Neuropsychology

JF - Archives of Clinical Neuropsychology

ER -

Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study

Abstract

Keywords

Disciplines

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