Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways

Hong Weng Pang; Andrea Linares; Leena Couling; Jessica Santollo; Leonardo Ancheta; Derek Daniels; Robert Charles Speth

doi:10.1007/s12020-019-01930-z

Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways

Hong Weng Pang
, Andrea Linares
, Leena Couling
, Jessica Santollo
, Leonardo Ancheta
, Derek Daniels
, Robert Charles Speth

Nova Southeastern University

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT

METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT

RESULTS: The BSA-Ang II conjugate was less potent competing for AT

CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT

Original language	American English
Journal	Endocrine
Volume	66
DOIs	https://doi.org/10.1007/s12020-019-01930-z
State	Published - Nov 1 2019

Keywords

AT1 receptor; Aldosterone release; Biased agonism; Bovine serum albumin-conjugated angiotensin II; Calcium mobilization; Salt appetite

Disciplines

Medicine and Health Sciences
Pharmacy and Pharmaceutical Sciences

Access to Document

10.1007/s12020-019-01930-zLicense: Unspecified

https://www.ncbi.nlm.nih.gov/pubmed/31020463

Cite this

@article{a67c340c43a24c1d9e4dddce0530c59f,

title = "Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways",

abstract = " PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT RESULTS: The BSA-Ang II conjugate was less potent competing for AT CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT",

keywords = "AT1 receptor; Aldosterone release; Biased agonism; Bovine serum albumin-conjugated angiotensin II; Calcium mobilization; Salt appetite",

author = "Pang, \{Hong Weng\} and Andrea Linares and Leena Couling and Jessica Santollo and Leonardo Ancheta and Derek Daniels and Speth, \{Robert Charles\}",

year = "2019",

month = nov,

day = "1",

doi = "10.1007/s12020-019-01930-z",

language = "American English",

volume = "66",

journal = "Endocrine",

issn = "1355-008X",

}

TY - JOUR

T1 - Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways

AU - Pang, Hong Weng

AU - Linares, Andrea

AU - Couling, Leena

AU - Santollo, Jessica

AU - Ancheta, Leonardo

AU - Daniels, Derek

AU - Speth, Robert Charles

PY - 2019/11/1

Y1 - 2019/11/1

N2 - PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT RESULTS: The BSA-Ang II conjugate was less potent competing for AT CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT

AB - PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT RESULTS: The BSA-Ang II conjugate was less potent competing for AT CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT

KW - AT1 receptor; Aldosterone release; Biased agonism; Bovine serum albumin-conjugated angiotensin II; Calcium mobilization; Salt appetite

UR - https://nsuworks.nova.edu/hpd_corx_facarticles/117

UR - https://www.ncbi.nlm.nih.gov/pubmed/31020463

U2 - 10.1007/s12020-019-01930-z

DO - 10.1007/s12020-019-01930-z

M3 - Article

C2 - 31020463

SN - 1355-008X

VL - 66

JO - Endocrine

JF - Endocrine

ER -

Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Fingerprint

Cite this